Inventors:
Andre Rosowsky - Needham MA
Ruth M. Ruprecht - Boston MA
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
C07H 1900
Abstract:
Compounds having the structure ##STR1## in which R is alkyl, aryl, or aralkyl, A is hydrogen or a water-soluble cation, B is hydrogen, fluorine, or azido, the bond is saturated when B is fluorine or azido and is saturated or unsaturated when B is hydrogen, and D is a purine or pyrimidine base are effective inhibitors of retrovirus replication.