DR. SETH LEO ALPER, M.D., PH.D.
Osteopathic Medicine in Boston, MA
License number
Massachusetts 53164
Category
Osteopathic Medicine
Type
Nephrology
Address
Address
330 EAST Rw-763 Beth Israel Deaconess Medical Ctr, Boston, MA 02215
Phone
(617) 667-2930
(617) 667-8040 (Fax)
(617) 667-8040 (Fax)
Personal information
See more information about SETH LEO ALPER at radaris.comName
Address
Phone
74 Orchard St, Jamaica Plain, MA 02130
Jamaica Plain, MA
330 Brookline Ave, Boston, MA 02215
74 Orchard St, Jamaica Plain, MA 02130
Professional information
Professor Of Medicine At Beth Israel Deaconess Medical Center
Position:
Professor of Medicine at Beth Israel Deaconess Medical Center
Location:
Greater Boston Area
Industry:
Hospital & Health Care
Work:
Beth Israel Deaconess Medical Center
-
Professor of Medicine
Seth Leo Alper, Boston MA
Specialties:
Internal Medicine, Nephrology
Work:
Beth Israel Deaconess Medical Center
330 Brookline Ave, Boston, MA 02215
330 Brookline Ave, Boston, MA 02215
Education:
Yale University (1980)
Dr. Seth L Alper - MD (Doctor of Medicine)
Hospitals:
330 Brookline Ave, Boston 02215
330 Brookline Ave, Boston 02215
330 Brookline Ave, Boston 02215
Education:
Medical Schools
Yale University School Of Medicine
Graduated: 1980
Yale University School Of Medicine
Graduated: 1980
Vacuolar Pyrophosphatases And Uses In Plants
US Patent:
2008010, May 1, 2008
Filed:
Aug 7, 2007
Appl. No.:
11/890795
Inventors:
Roberto Gaxiola - Tempe AZ, US
Gerald Fink - Chestnut Hill MA, US
Seth Alper - Boston MA, US
Gerald Fink - Chestnut Hill MA, US
Seth Alper - Boston MA, US
International Classification:
C12N 15/82, A01H 1/06, C12N 5/10, A01H 5/00
US Classification:
800290000, 435419000, 435411000, 435412000, 800298000, 800320200, 800317300, 800320000, 800307000, 800305000, 800320100, 800278000
Abstract:
The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The present invention also relates to a transgenic plant with increased Pi uptake, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. Plant cells (e.g., root cells, stem cell, leaf cells, flower cells, fruit cells and seed cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. Transgenic plants produced by the methods of making a transgenic plant as described herein are also a subject of the present invention. The present invention also relates to a method of bioremediating soil, a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, a method of producing a transgenic plant which grows in salt water, and a method of producing a transgenic plant with increased Pi uptake. The transgenic plants of the present invention can also be used to produce double transgenic plants which are tolerant to a salt, or have increased Pi uptake.
Proton Transporters And Uses In Plants
US Patent:
2002017, Nov 28, 2002
Filed:
Apr 13, 2001
Appl. No.:
09/834998
Inventors:
Roberto Gaxiola - Mansfield Center CT, US
Gerald Fink - Chestnut Hill MA, US
Seth Alper - Boston MA, US
Gerald Fink - Chestnut Hill MA, US
Seth Alper - Boston MA, US
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A01H005/00
US Classification:
800/278000, 800/317300, 800/320100, 800/317400
Abstract:
The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. The present invention also relates to a construct comprising an AVP1 gene operably linked to a chimeric promoter designed to overexpress AVP1 or designed to down regulate endogenous pyrophosphatase. Plant cells (e.g., root cells, stem cell, leaf cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. Transgenic plants produced by the methods of making a transgenic plant as described herein are also a subject of the present invention. The present invention also relates to a method of bioremediating soil, a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, and a method of producing a transgenic plant which grows in salt water comprising introducing into one or more cells of a plant nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The transgenic plants of the present invention can also be used to produce double transgenic plants which are tolerant to a salt.
Transgenic Pollen Expressing Exogenous Plant Vacuolar Pyrophosphatase And Methods For Increasing Seed Production In Plants
US Patent:
8168864, May 1, 2012
Filed:
May 23, 2005
Appl. No.:
11/135165
Inventors:
Roberto A. Gaxiola - Mansfield Center CT, US
Seth L. Alper - Boston MA, US
Gerald R. Fink - Chestnut Hill MA, US
Seth L. Alper - Boston MA, US
Gerald R. Fink - Chestnut Hill MA, US
Assignee:
Beth Israel Deaconess Medical Center - Boston MA
International Classification:
A01H 5/00, C12N 15/82, C12N 5/04
US Classification:
800295, 800298, 800278, 800289, 800290, 435419, 435468
Abstract:
Methods are provided for imparting desirable phenotypic traits to transgenic plants, among them being increased tolerance to external stresses such as drought, freezing temperatures, high salt conditions, and the like. In addition, the present invention is directed toward methods for increasing the yield of seeds from plants by using the pollen from a transgenic plant transformed to overexpress a vacuolar proton-pumping pyrophosphatase to fertilize plants, and to the pollen of transgenic plants itself.
Plant Cells And Plants Overexpressing Vacuolar Proton Pyrophosphatases
US Patent:
8058515, Nov 15, 2011
Filed:
May 2, 2005
Appl. No.:
11/119683
Inventors:
Roberto A. Gaxiola - Mansfield Center CT, US
Seth L. Alper - Boston MA, US
Gerald R. Fink - Chestnut Hill MA, US
Seth L. Alper - Boston MA, US
Gerald R. Fink - Chestnut Hill MA, US
Assignee:
University of Connecticut - Farmington CT
Beth Israel Deaconess Medical Center - Boston MA
Whitehead Institute for Biomedical Research - Cambridge MA
Beth Israel Deaconess Medical Center - Boston MA
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A01H 5/00, C12N 15/82, C12N 5/04
US Classification:
800295, 800298, 800278, 800289, 800290, 435419, 435468
Abstract:
The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plants grown from seed are also described. Plant cells (e. g. , root cells, stem cells, leaf cells) comprising exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant cells are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. The present invention also relates to a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, and a method of producing a transgenic plant with increased salt tolerance.
Methods And Compound To Inhibit Ca2+ Permeable Cation Conductance
US Patent:
2012018, Jul 19, 2012
Filed:
Jan 17, 2012
Appl. No.:
13/351611
Inventors:
Frederick Sachs - Buffalo NY, US
Philip Gottlieb - Buffalo NY, US
Thomas Suchyna - Amherst NY, US
Seth L. Alper - Boston MA, US
David H. Vandorpe - Watertown MA, US
Chang Xu - Mount Kisco NY, US
Philip Gottlieb - Buffalo NY, US
Thomas Suchyna - Amherst NY, US
Seth L. Alper - Boston MA, US
David H. Vandorpe - Watertown MA, US
Chang Xu - Mount Kisco NY, US
International Classification:
A61K 38/16, C12N 5/02, A61P 7/06
US Classification:
514 135, 435375
Abstract:
The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
Method For Reducing Chloride Secetion By Intestinal Epithlial Cells In Situ
US Patent:
2002000, Jan 10, 2002
Filed:
Sep 23, 1998
Appl. No.:
09/159331
Inventors:
WAYNE I. LENCER - JAMAICA PLAINS MA, US
CARLO BRUGNARA - NEWTON HIGHLANDS MA, US
SETH ALPER - JAMAICA PLAIN MA, US
CARLO BRUGNARA - NEWTON HIGHLANDS MA, US
SETH ALPER - JAMAICA PLAIN MA, US
International Classification:
A61K031/40, A61K031/335, A61K031/35, A61K031/34
US Classification:
514/409000, 514/414000, 514/418000, 514/450000, 514/451000, 514/461000, 514/475000, 514/867000
Abstract:
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
Use Of 11-Phenyl-Dibenzazepine Compounds To Treat Diarrhea Or Scours
US Patent:
6291449, Sep 18, 2001
Filed:
Sep 23, 1998
Appl. No.:
9/159333
Inventors:
Wayne I. Lencer - Jamaica Plains MA
Carlo Brugnara - Newton Highlands MA
Seth Alper - Jamaica Plain MA
Carlo Brugnara - Newton Highlands MA
Seth Alper - Jamaica Plain MA
Assignee:
Children's Medical Center Corporation - Boston MA
Beth Israel Deaconess Medical Center - Boston MA
Beth Israel Deaconess Medical Center - Boston MA
International Classification:
A61K 3155
US Classification:
514217
Abstract:
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.