JEFFREY DOYON, M.D.
Osteopathic Medicine at Francis St, Boston, MA
License number
Massachusetts 259208
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
75 Francis St, Boston, MA 02115
Phone
(617) 732-5500
Personal information
See more information about JEFFREY DOYON at radaris.comName
Address
Phone
71 Aldie St #3, Allston, MA 02134
Professional information
Evolving New Molecular Function
US Patent:
2005017, Aug 4, 2005
Filed:
Sep 24, 2004
Appl. No.:
10/950367
Inventors:
David Liu - Lexington MA, US
Zev Gartner - Somerville MA, US
Jeffrey Doyon - Allston MA, US
Christopher Calderone - Cambridge MA, US
Matthew Kanan - Cambridge MA, US
Xiaoyu Li - Cambridge MA, US
Thomas Snyder - Cambridge MA, US
Daniel Rosenbaum - Somerville MA, US
Zev Gartner - Somerville MA, US
Jeffrey Doyon - Allston MA, US
Christopher Calderone - Cambridge MA, US
Matthew Kanan - Cambridge MA, US
Xiaoyu Li - Cambridge MA, US
Thomas Snyder - Cambridge MA, US
Daniel Rosenbaum - Somerville MA, US
International Classification:
C12Q001/68, C12P019/34
US Classification:
435006000, 435091200
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
In Vivo Selection System For Enzyme Activity
US Patent:
2009026, Oct 22, 2009
Filed:
Jan 12, 2009
Appl. No.:
12/352292
Inventors:
David R. Liu - Lexington MA, US
Zev Gartner - Somerville MA, US
Daniel M. Rosenbaum - Cambridge MA, US
Mathias Gruen - Jena, DE
Jeffrey Doyon - Allston MA, US
Zev Gartner - Somerville MA, US
Daniel M. Rosenbaum - Cambridge MA, US
Mathias Gruen - Jena, DE
Jeffrey Doyon - Allston MA, US
International Classification:
C12Q 1/02, C12N 1/21
US Classification:
435 29, 43525233
Abstract:
The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides methods of making cells in which the activity of a biological cleavage enzyme is linked to viability, as well as methods of identifying new biological cleavage enzymes, including enzymes having altered site specificity, using such cells.
In Vivo Selection System For Enzyme Activity
US Patent:
7476500, Jan 13, 2009
Filed:
Mar 19, 2002
Appl. No.:
10/102056
Inventors:
David R. Liu - Lexington MA, US
Zev Gartner - Somerville MA, US
Daniel M. Rosenbaum - Cambridge MA, US
Mathias Gruen - Jena, DE
Jeffrey Doyon - Allston MA, US
Zev Gartner - Somerville MA, US
Daniel M. Rosenbaum - Cambridge MA, US
Mathias Gruen - Jena, DE
Jeffrey Doyon - Allston MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12Q 1/68, C12N 9/22
US Classification:
435 6, 435199
Abstract:
The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides methods of making cells in which the activity of a biological cleavage enzyme is linked to viability, as well as methods of identifying new biological cleavage enzymes, including enzymes having altered site specificity, using such cells.
Evolving New Molecular Function
US Patent:
8206914, Jun 26, 2012
Filed:
Jul 12, 2010
Appl. No.:
12/834072
Inventors:
David R. Liu - Lexington MA, US
Zev J. Gartner - Santa Cruz CA, US
Jeffrey B. Doyon - Allston MA, US
Christopher T. Calderone - Boston MA, US
Matthew W. Kanan - Cambridge MA, US
Xiaoyu Li - Cambridge MA, US
Thomas M. Snyder - Cambridge MA, US
Daniel M. Rosenbaum - Burlingame CA, US
Zev J. Gartner - Santa Cruz CA, US
Jeffrey B. Doyon - Allston MA, US
Christopher T. Calderone - Boston MA, US
Matthew W. Kanan - Cambridge MA, US
Xiaoyu Li - Cambridge MA, US
Thomas M. Snyder - Cambridge MA, US
Daniel M. Rosenbaum - Burlingame CA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12Q 1/68
US Classification:
435 61
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.