Inventors:
Eric Rubin - Belle Mead NJ, US
Ahamed Saleem - Highland Park NJ, US
Zeshaan Rasheed - Piscataway NJ, US
Paul Haluska - Rochester MN, US
Assignee:
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
International Classification:
C12Q001/68, G01N033/574, A61K048/00, A61K038/17, C07K016/40
US Classification:
514/012000, 514/044000, 435/006000, 435/007230, 530/388260, 424/093200
Abstract:
Topors and topors antibody can be used to manipulate the presence and function of both Top1 and p53 in cells, thus controlling the function of the Top1 and p53 proteins. Topors is implicated in prevention of tumorigenesis through its role in DNA repair and preventing faulty or mutated DNA from replicating. Topors can be used therapeutically as a medicament and topors DNA can be used in gene therapy. Topors antibody may be used to detect the presence of cancer by screening for the absence of topors in a given cell or tissue sample. Kits comprising the topors antibody are also contemplated.