Inventors:
Sydney Welt - New York NY, US
Nancy Kemeny - New York NY, US
Gerd Ritter - New York NY, US
Achim Jungbluth - New York NY, US
Leonard Cohen - New york NY, US
Lloyd Old - New York NY, US
International Classification:
A61K039/395, A61K031/525, A61K031/4745
US Classification:
424/142100, 514/050000, 514/251000, 514/283000
Abstract:
This invention relates to a combination of immunotherapy and chemotherapy to promote tumor regression by treating a patient in need thereof with a combination of a humanized antibody that binds to A33 antigen and one or more chemotherapeutic agents. The method is useful for treating patients with colorectal cancer and gastric carcinomas. The method is particularly useful for treating patients who have tumors that are resistant to one or more chemotherapeutic agents and/or have metastasized.