Inventors:
Atul J. Butte - Stanford CA, US
Kenneth Weinberg - Stanford CA, US
Maheswaran Mani - Sunnyvale CA, US
International Classification:
A61K 39/395, C12Q 1/02, C12Q 1/06, A61P 35/00, A61P 35/02, A61P 7/06, G01N 33/566, C12Q 1/68
US Classification:
4241581, 435 721, 435 29, 435 612, 435 39
Abstract:
Methods and compositions are provided for modulating Kit/stem cell factor receptor (SCFR)/CD117 and interleukin 4 receptor (IL-4R) signaling in a cell in vitro and in vivo, and for identifying candidate agents with activity in modulating Kit and IL-4R signaling. These methods find particular use in treating disorders of the hematopoietic system and in modulating hematopoietic stem cell expansion.