DR. STEPHEN JOSEPH GALLI, M.D.
Medical Practice in Palo Alto, CA
License number
California G85246
Category
Medical Practice
Type
Anatomic Pathology
Address
Address
300 Stanford University Medical Ctr, Palo Alto, CA 94305
Phone
(650) 723-7975
(650) 725-6902 (Fax)
(650) 725-6902 (Fax)
Professional information
Stephen Joseph Galli, Stanford CA
Specialties:
Pathology, Anatomic Pathology, Clinical Pathology/Laboratory Medicine, Allergy, Hematology, Infectious Disease
Work:
Stanford Hospital and Clinics
300 Pasteur Dr, Stanford, CA 94305
300 Pasteur Dr, Stanford, CA 94305
Education:
Harvard University(1973)
Neurotensin As A Marker And Therapeutic Target For Sepsis
US Patent:
8449864, May 28, 2013
Filed:
Oct 19, 2007
Appl. No.:
11/875710
Inventors:
Adrian Martin Piliponsky - Mountain View CA, US
Mindy Tsai - Palo Alto CA, US
Stephen J. Galli - Stanford CA, US
Mindy Tsai - Palo Alto CA, US
Stephen J. Galli - Stanford CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61B 5/145, G01N 33/49, C07K 16/00
US Classification:
424 91, 435 71, 435 795, 5303871
Abstract:
Sepsis is a complex, incompletely understood and often fatal disorder, typically accompanied by hypotension, that is considered to represent a dysregulated host response to an infection. Neurotensin (NT) is 13-amino-acid peptide that, among its multiple effects, induces hypotension. It is shown herein that plasma concentrations of NT are increased in humans with sepsis and in mice after caecal ligation and puncture (CLP), a model of sepsis. Mast cells can degrade NT through neurotensin receptor 1-and neurolysin-dependent mechanisms, diminishing the hypotensive effects of NT, reducing intraperitoneal NT concentrations, and improving survival. These findings show that mast cells can regulate NT concentrations, and identify NT as a biomarker and therapeutic target in sepsis.
Dr. Stephen J Galli, Stanford CA - MD (Doctor of Medicine)
Specialties:
Anatomic Pathology, Allergy & Immunology, Immunology
Address:
300 Pasteur Dr STE 235, Stanford 94305
(650) 723-7975 (Phone), (650) 725-6902 (Fax)
STANFORD UNIVERSITY MEDICAL CENTER
300 Pasteur Dr STE HH-333, Stanford 94305
(650) 725-8623 (Phone), (650) 725-9877 (Fax)
(650) 723-7975 (Phone), (650) 725-6902 (Fax)
STANFORD UNIVERSITY MEDICAL CENTER
300 Pasteur Dr STE HH-333, Stanford 94305
(650) 725-8623 (Phone), (650) 725-9877 (Fax)
Languages:
English
Hospitals:
300 Pasteur Dr STE 235, Stanford 94305
STANFORD UNIVERSITY MEDICAL CENTER
300 Pasteur Dr STE HH-333, Stanford 94305
Stanford Hospital and Clinics
300 Pasteur Dr, Stanford 94305
STANFORD UNIVERSITY MEDICAL CENTER
300 Pasteur Dr STE HH-333, Stanford 94305
Stanford Hospital and Clinics
300 Pasteur Dr, Stanford 94305
Education:
Medical School
Harvard Medical School
Graduated: 1973
Mass Gen Hospital
Harvard Medical School
Graduated: 1973
Mass Gen Hospital
Methods For Screening For Modulators Of Ccrl2
US Patent:
2010009, Apr 15, 2010
Filed:
Aug 13, 2009
Appl. No.:
12/541056
Inventors:
Brian A. Zabel - Redwood City CA, US
Eugene C. Butcher - Portola Valley CA, US
Stephen J. Galli - Stanford CA, US
Susumu Nakae - Machida, JP
Luis Zuniga - Palo Alto CA, US
Eugene C. Butcher - Portola Valley CA, US
Stephen J. Galli - Stanford CA, US
Susumu Nakae - Machida, JP
Luis Zuniga - Palo Alto CA, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin.