DAVID JAY SCHURMAN
Medical Practice at Blake Wilbur Dr, Palo Alto, CA

6528052, Mar 4, 2003

Sep 29, 2000

09/677109

R. Lane Smith - Palo Alto CA
Dennis R. Carter - Stanford CA
David J. Schurman - Stanford CA

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

C12N 500

424 937

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.

6383226, May 7, 2002

Jun 9, 1998

09/094230

Dennis R. Carter - Stanford CA
Jay A. Mandell - Saratoga CA
David J. Schurman - Stanford CA

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

A61F 236

623 2321

Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.

2009017, Jul 9, 2009

Jul 11, 2008

11/980967

R. Lane Smith - Palo Alto CA, US
Dennis R. Carter - Stanford CA, US
David J. Schurman - Stanford CA, US

C12N 5/08, C12N 5/06

435366, 435325

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

7835559, Nov 16, 2010

Apr 27, 2007

11/741657

David J. Schurman - Stanford CA, US
Robert Lane Smith - Palo Alto CA, US

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

G06K 9/00, G01N 23/05

382128, 25039002

A system for determining image intensity of a radiograph includes an illuminator for providing lighting to the radiograph, an image reference standard having a predetermined color, a digital imaging device for obtaining a digital image of the radiograph and the image reference standard, a computer for receiving and storing the digital image and for executing programs, and an image analysis program being executed on the computer for providing a first image intensity value of a target area in the radiograph and a second image intensity value of the image reference standard and for computing a normalized image intensity value of the target area using the first and second image intensity values. In one embodiment, the image reference standard is an image reference standard of a black color or a white color.

7892799, Feb 22, 2011

Aug 30, 2007

11/897911

Robert Lane Smith - Palo Alto CA, US
Dennis R. Carter - Stanford CA, US
David J. Schurman - Stanford CA, US

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC

C12N 5/00

4351738, 424548, 424 937, 601 1, 601 2

A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

4358859, Nov 16, 1982

Oct 4, 1979

6/081713

David J. Schurman - Stanford CA
Robert L. Piziali - Stanford CA

A61F 103

3 1911

An articulated knee prosthesis in which a femoral implant has a condyle section and a femoral stem that is cemented into the femur. A tibial implant carries a tibial plateau section on which is mounted a stop plate for engaging the condyle section and arresting movement of the knee beyond its fully extended position. The tibial implant includes a tibial stem that is cemented into the tibia. A pivotal connection between the two implants is positioned posteriorly of the implant and at an elevation above a lowermost point of the condyle section (when the implants are fully extended). The pivot axis of the connection and the stems are positioned with respect to each other so that upon the implantation of the implant, the patient's tibia is moved in an anterior direction as compared to the normal anatomical position of the tibia relative to the femur. At least a portion of the hinged connection, which frequently includes the pivot axis, is located posteriorly of portions of the femur proximate the knee joint to maximize the arc through which the knee can be flexed.

2003013, Jul 17, 2003

Dec 24, 2002

10/328387

R. Smith - Palo Alto CA, US
Dennis Carter - Stanford CA, US
David Schurman - Stanford CA, US

C12Q001/68, A61M029/00

424/093700, 424/422000, 435/006000

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.