Inventors:
Jeffrey Molldrem - Houston TX, US
A. Barrett - Silver Spring MD, US
International Classification:
A61K 39/00, A61K 39/395, A61K 38/16, A61K 33/40, A61K 33/24
US Classification:
424185100, 424277100, 424649000, 514034000, 514109000, 514410000, 514449000, 514008000, 514027000, 424616000, 424155100
Abstract:
The present provides tumor-associated HLA-restricted antigens, and in particular HLA-A2 restricted antigens, as vaccines for treating or preventing cancers in a patient. In specific aspects, there is proteinase 3 peptides are provided. Such peptides can be used to elicit specific CTLs that preferentially attack myeloid leukemia based on overexpression of the target protein cells.