CHRISTOPHER J. LOGOTHETIS, M.D.
Osteopathic Medicine at Holcombe Blvd, Houston, TX

6517828, Feb 11, 2003

May 26, 2000

09/580043

Sue-Hwa Lin - Houston TX
Weiping Luo - Pearland TX
Christopher Logothetis - Houston TX

Board of Regents, The University of Texas System - Austin TX

C12N 1579

424 932, 536 235, 530350, 4353201, 514 44

The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is necessary and sufficient for inhibiting angiogenesis. In particular embodiments, it relates to inhibiting hyperproliferative cell growth by administering to a cell a C-CAM1 cytoplasmic domain or an expression construct encoding a C-CAM1 cytoplasmic domain. In other embodiments, angiogenesis is inhibited by administering to a subject a C-CAM1 polypeptide or an expression construct encoding a C-CAM1 polypeptide.

5728815, Mar 17, 1998

Jan 7, 1994

8/179569

Leland W. K. Chung - Houston TX
James Chan - Sugarland TX
Christopher Logothetis - Houston TX

Board of Regents, The University of Texas System - Austin TX

C07K 14475

530399

The role for a substantially purified human growth factor preparation is shown to contain a distinct polypeptide with apparent M. sub. r on SDS/PAGE of about 220 kD, and to be distinct from bFGF, with a most active fraction at about 220 kD. A human growth factor polypeptide of 157 kD was identified, in human bone marrow aspirates and from bone stromal cells, by immunoblotting with the mAb MS 329, and by affinity isolation using a MS 329 antibody column. A PSA stimulating autocrine factor, PSAF, that is precipitable in ammonium sulfate at between 60-80% saturation is able to induce PSA expression and secretion, and serves as an indicator of androgen independent prostate cell growth.

5679636, Oct 21, 1997

Nov 15, 1994

8/341297

Leland W. K. Chung - Houston TX
James C. Chan - Sugarland TX
Christopher J. Logothetis - Houston TX

Board of Regents, The University of Texas - Austin TX

A61K 3818, C07K 14475, A23J 100

514 2

The role of tumor cell-host stromal interaction and stromal-specific growth factors in prostate cancer growth, progression and metastasis to the axial skeleton were investigated. Following co-inoculation of athymic mice with human prostate cancer cells (LNCaP) and various nontumorigenic fibroblasts, human prostate-like tumor formation was consistently induced by human bone (MS) fibroblasts (62%), embryonic rat urogenital sinus mesenchymal (rUGM) cells (31%) and Noble rat prostatic fibroblasts (17%), but not by NIH-3T3, normal rat kidney (NRK), or human lung CCD16 fibroblasts. Carcinomas formed preferentially in male hosts, demonstrating in vivo androgen sensitivity. A novel in vivo method in which a slowly adsorbed matrix (Gelfoam) was employed to deliver concentrated prostate and bone fibroblast-derived conditioned media was also found to induce LNCaP tumor formation in vivo. Such in vivo growth-promoting effects correlated with in vitro tests employing a soft agar colony-forming assay using rat prostate epithelial (NbE-1) cells as targets. A substantially purified human growth factor preparation is shown to contain distinct polypeptides with apparent M. sub.