Inventors:
Razelle Kurzrock - Houston TX, US
Lan Li - Houston TX, US
Kapil Mehta - Houston TX, US
Bharat B. Aggarwal - Houston TX, US
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
A61K 9/14, A61P 35/00, A61K 9/51, A61K 9/19, A61K 31/12, A61K 9/127
US Classification:
424450, 424489, 514679, 424501, 424451
Abstract:
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analogue is administered parenterally in a pharmaceutically acceptable carrier.