Inventors:
Francine Foss - Woodbridge CT, US
Yong Xie - Belmont MA, US
Assignee:
NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. - Boston MA
International Classification:
A61K 38/19, A61K 35/14
US Classification:
424085100, 424093700, 607086000
Abstract:
Methods and compositions are provided for the treatment of an autoimmune disease. The methods include administering immunoregulatory T cells (T) to patients. The therapeutic Tcan express the CD25, CD4, and/or ICOS antigens. The therapeutic T cells can be CD25 ICOS, CD4ICOS, and/or CD25 CD4 ICOS, and they can be provided by a donor.