Inventors:
Michael Reiss - Princeton NJ, US
Judy Kleinstein - Woodbridge CT, US
International Classification:
A61K 39/395, G01N 33/53, C12Q 1/68, C40B 30/00, C40B 40/06
US Classification:
4241581, 435 772, 435 6, 506 7, 506 16
Abstract:
Methods are disclosed for determining the optimal biologic dose of a TGFβ receptor kinase inhibitor for administration to patients in need of such therapy and for monitoring the effectiveness of therapy with a TGFβ receptor kinase inhibitor in patients receiving such therapy. Kits comprising antibodies and reagents useful in such methods are also disclosed.