DEAN D. METCALFE, M.D.
Osteopathic Medicine in Bethesda, MD
License number
Maryland D0019078
Category
Osteopathic Medicine
Type
Allergy & Immunology
License number
Maryland D0019078
Category
Osteopathic Medicine
Type
Rheumatology
Address
Address
10 Center Dr, Bethesda, MD 20892
Phone
(301) 496-2165
(301) 480-8384 (Fax)
(301) 480-8384 (Fax)
Professional information
Dean D Metcalfe, Bethesda MD
Specialties:
Rheumatologist
Address:
10 Center Dr, Bethesda, MD 20892
Education:
University of Tennessee, College of Medicine - Doctor of Medicine
University of Michigan - Master of Science in Electrical Engineering
Brigham & Women's Hospital - Fellowship - Rheumatology (Internal Medicine)
National Institutes of Health-Clinical Center - Residency - Allergy and Immunology
University of Michigan Health System - Residency - Internal Medicine
University of Michigan Health System - Internship - Internal Medicine
University of Michigan - Master of Science in Electrical Engineering
Brigham & Women's Hospital - Fellowship - Rheumatology (Internal Medicine)
National Institutes of Health-Clinical Center - Residency - Allergy and Immunology
University of Michigan Health System - Residency - Internal Medicine
University of Michigan Health System - Internship - Internal Medicine
Board certifications:
American Board of Allergy and Immunology Certification in Allergy and Immunology, American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Rheumatology (Internal Medicine)
Dr. Dean D Metcalfe, Bethesda MD - MD (Doctor of Medicine)
Specialties:
Rheumatology
Address:
10 Ctr Dr STE 10, Bethesda 20892
(301) 496-2165 (Phone), (301) 480-8384 (Fax)
(301) 496-2165 (Phone), (301) 480-8384 (Fax)
Certifications:
Allergy & Immunology, 1977, Internal Medicine, 1975, Rheumatology, 1980
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of Tennessee / Memphis / College of Medicine & Surgery
Graduated: 1972
Michigan Hospitals
National Institutes Of Health Clinical Center
Rb Brigham Hosp
University of Tennessee / Memphis / College of Medicine & Surgery
Graduated: 1972
Michigan Hospitals
National Institutes Of Health Clinical Center
Rb Brigham Hosp
Dean Darrel Metcalfe, Bethesda MD
Specialties:
Allergy & Immunology, Internal Medicine, Rheumatology, Pathology
Work:
National Institutes of Health
10 Ctr Dr, Bethesda, MD 20892
10 Ctr Dr, Bethesda, MD 20892
Education:
University of Tennessee (1972)
Ige-Binding Epitopes Of A Major Heat-Stable Crustacean Allergen Derived From Shrimp
US Patent:
5449669, Sep 12, 1995
Filed:
Nov 10, 1993
Appl. No.:
8/149809
Inventors:
Dean D. Metcalfe - Bethesda MD
Brian M. Martin - Bethesda MD
Pillarisetti V. S. Roa - Bangalore, IN
Brian M. Martin - Bethesda MD
Pillarisetti V. S. Roa - Bangalore, IN
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
C07K 706, C07K 708, A61K 3808, A61K 3810
US Classification:
514 13
Abstract:
A major heat-stable shrimp allergen is characterized as a 34 kDa protein corresponding to shrimp tropomyosin. Two IgE binding epitopes of this allergen have the sequences FLAEEADRK (SEQ ID NO: 1) and MQQLENDLDQVQESLLK (SEQ ID NO: 2), respectively. Surprisingly, both antigenic and allergenic activities of the allergen were found to be associated with these two peptide fractions. A-a-id antibodies recognized this allergen as well as a homologous 34 kDa allergen from lobster, prawn and crab, indicating that these antibodies recognize major cross-reacting IgE binding epitopes common to crustacea. The two epitopes are useful in the diagnosis and/or treatment of allergies, particularly in the desensitization of individuals that are allergic to shrimp and other crustacea. Variants and subfragments of the two epitopes display allergenicity, as assessed by reaction with allergen-specific IgE obtained from shrimp-sensitive patients.