DR. PAOLO B DEPETRILLO, MD
Osteopathic Medicine at Sangamore Rd, Bethesda, MD

6448245, Sep 10, 2002

May 2, 2001

09/847872

Paolo B. DePetrillo - Bethesda MD
Wenshuai Wan - Ellicott City MD

The United States of America as represented by the Department of Health and Human Services - Washington DC

A61K 3155

514218, 51425213, 514311, 514365, 514461

A method is disclosed for inhibiting calpain by contacting calpain with one or more HIV protease inhibitors or analogs. Included are embodiments for identifying subjects at risk of suffering calpain-mediated physiological damage and administering to them the HIV protease inhibitors or analogs. Alternatively, a compound may be administered to a subject following an actual event implicating activation of calpain. Also included are methods of treating or preventing calpain-mediated physiological damage in a subject by administering to the subject a therapeutically effective amount of a pharmaceutical composition which includes at least one HIV protease inhibitor or analog. The pharmaceutical compositions can be used in the treatment of a variety of conditions or diseases implicated by or associated with calpain activation, including cardiovascular diseases.

6144877, Nov 7, 2000

Aug 11, 1998

9/132462

Paolo B. DePetrillo - Bethesda MD

The United States of America as represented by the Department of Health
and Human Services - Washington DC

A61B 500, A61B 504

600515

Statistical information is determined for time series data of a measurable activity. The time series data of the measurable activity is obtained and comprises data elements representative of the measurable activity. A Hurst exponent is determined from the time series data and is the statistical information of the time series data.