YOUNG H KWON, MD PHD
Medical Practice at Hawkins Dr, Iowa City, IA

2011020, Aug 25, 2011

Nov 12, 2010

12/945246

Erin Lavik - Cleveland Heights OH, US
James Bertram - New Haven CT, US
Sandeep Saluja - Fair Lawn NJ, US
Markus Kuehn - Amana IA, US
Young H. Kwon - Iowa City IA, US
Rebecca Robinson - East Point GA, US
John J. Huang - Hamden CT, US

A61K 9/14, A61K 31/573, A61K 31/216, A61K 31/517, A61P 27/02, B65D 69/00

424501, 424489, 514179, 514180, 514530, 5142664, 206223

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye.

2007009, Apr 26, 2007

Oct 9, 2006

11/545226

Randy Kardon - Iowa City IA, US
Young Kwon - Iowa City IA, US
Daniel Tso - Jamesville NY, US
Peter Soliz - Albuquerque NM, US
David Abramoff - University Heights IA, US

A61B 3/14

351206000

An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

8492334, Jul 23, 2013

Jun 18, 2008

12/664792

Erin Lavik - Branford CT, US
Young H. Kwon - Iowa City IA, US
Markus Kuehn - Amana IA, US
Sandeep Saluja - Fair Lawn NJ, US
James Bertram - New Haven CT, US
John Huang - Hamden CT, US

Yale University - New Haven CT
University of Iowa Research Foundation - Iowa City IA

A61K 38/18, A61K 38/22, A61K 31/7036, A61K 31/704, A61K 31/57, A61K 31/573

514 76, 514 97, 514 36, 514 37, 514300

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing one or more diseases or disorders of the eye, and methods of making and using thereof, are described. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (IOP) in the eye. Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time.

7118217, Oct 10, 2006

Jan 17, 2003

10/347142

Randy H. Kardon - Iowa City IA, US
Young H. Kwon - Iowa City IA, US
Daniel Tso - Jamesville NY, US
Peter Soliz - Albuquerque NM, US

University of Iowa Research Foundation - Iowa City IA
The Research Foundation of State Univ. of New York - Albany NY
Kestrel Corporation - Albuquerque NM

A61B 3/14, A61B 3/10

351206, 351221, 600473, 600476

An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

7712898, May 11, 2010

Apr 3, 2007

11/695779

Michael D. Abramoff - Iowa City IA, US
Young Kwon - Iowa City IA, US

University of Iowa Research Foundation - Iowa City IA

A61B 3/14, A61B 3/10

351206, 351210, 351221

A method of classifying an optic nerve cup and rim of an eye from a retinal image comprising receiving a retinal image, determining a feature vector for a candidate pixel in the retinal image, and classifying the candidate pixel as a cup pixel or a rim pixel based on the feature vector using a trained classifier. The retinal image can be a stereo pair, the retinal image can be color or monochrome. The method disclosed can further comprise identifying an optic nerve, identifying an optic nerve cup and optic nerve rim, and determining a cup-to-disc ratio.