EDWIN M STONE, MD
Medical Practice at Hawkins Dr, Iowa City, IA
License number
Iowa 27053
Category
Medical Practice
Type
Ophthalmology
Address
Address
200 Hawkins Dr, Iowa City, IA 52242
Phone
(319) 335-8270
(319) 335-7142 (Fax)
(319) 335-7142 (Fax)
Professional information
Glaucoma Therapeutics And Diagnostics
US Patent:
6403307, Jun 11, 2002
Filed:
Apr 7, 1998
Appl. No.:
09/056285
Inventors:
Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
John Fingert - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
John Fingert - Iowa City IA
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C12Q 168
US Classification:
435 6, 435 912, 536 231, 536 243
Abstract:
Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.
Glaucoma Therapeutics And Diagnostics Based On A Novel Human Transcription Factor
US Patent:
6207450, Mar 27, 2001
Filed:
May 22, 1998
Appl. No.:
9/083352
Inventors:
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Edwin M. Stone - Iowa City IA
Darryl Nishimura - Coralville IA
Shiva Patil - Iowa City IA
Wallace L. M. Alward - Iowa City IA
Edwin M. Stone - Iowa City IA
Darryl Nishimura - Coralville IA
Shiva Patil - Iowa City IA
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C12N5/10;15/63
US Classification:
435325
Abstract:
Methods and compositions for treating glaucoma and methods and compositions for prognosing or diagnosing glaucoma in a subject are disclosed.
Identification Of A Gene Causing The Most Common Form Of Bardet-Biedl Syndrome And Uses Thereof
US Patent:
6962788, Nov 8, 2005
Filed:
May 28, 2003
Appl. No.:
10/447322
Inventors:
Val C. Sheffield - Iowa City IA, US
Kirk Mykytyn - Iowa City IA, US
Darryl Y. Nishimura - Coralville IA, US
Edwin M. Stone - Iowa City IA, US
Charles C. Searby - Iowa City IA, US
Kirk Mykytyn - Iowa City IA, US
Darryl Y. Nishimura - Coralville IA, US
Edwin M. Stone - Iowa City IA, US
Charles C. Searby - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
G01N033/68, C12P021/02, C12N015/63, C07H021/04
US Classification:
435 71, 435 691, 4353201, 530350, 536 235
Abstract:
The present invention relates to the identification of a gene, mutated at the most common locus now designated BBS1, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypogonadism, mental retardation, renal cancer and other renal abnormalities, retinopathy and polydactyly or limb deformities. The human BBS1 protein disclosed herein is composed of 17 exons and spans approximately 23 kb. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
Device And Process For Staining Electrophoretic Gels
US Patent:
5458749, Oct 17, 1995
Filed:
May 2, 1994
Appl. No.:
8/236967
Inventors:
Edwin M. Stone - Iowa City IA
Brian E. Nichols - Iowa City IA
Brian E. Nichols - Iowa City IA
Assignee:
Univeristy of Iowa Research Foundation - Iowa City IA
International Classification:
G01N 2726, G01N 27447
US Classification:
2041801
Abstract:
A process and apparatus are described herein which provide for the automated processing of electrophoresed gels having biological material thereon within a single processing chamber. The described apparatus is implemented by control sequencing software to stain process electrophoretic gels by contact with a series of recirculated solutions including fixing, rinsing, staining, and developing solutions.
Alterations Of Fibulin Genes In Macular Degeneration
US Patent:
2006002, Feb 2, 2006
Filed:
Feb 24, 2005
Appl. No.:
11/065695
Inventors:
Edwin Stone - Iowa City IA, US
International Classification:
C12Q 1/68, C12P 19/34
US Classification:
435006000, 435091200
Abstract:
The present invention involves the identification of mutations in various fibulin genes that contribute to age-related macular degeneration (AMD). Compositions and methods are provided to predict, diagnose and treat AMD using fibulin-1, fibulin-2, fibulin-4, fibulin-5 and fibulin-6 as targets.
Bardet-Biedl Susceptibility Gene And Uses Thereof
US Patent:
8129161, Mar 6, 2012
Filed:
Oct 20, 2010
Appl. No.:
12/908707
Inventors:
Val Sheffield - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US
Assignee:
The University of Iowa Research Foundation - Iowa City IA
International Classification:
C12N 15/63
US Classification:
435183, 4353201, 536 235
Abstract:
The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human NGVN protein disclosed herein is 731 amino acids in length and is coded for by a gene spanning 17 exons. Homologs have been identified in mouse, rat, zebrafish. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
Bardet-Biedl Susceptibility Gene And Uses Thereof
US Patent:
7947479, May 24, 2011
Filed:
Mar 7, 2006
Appl. No.:
11/370242
Inventors:
Val Sheffield - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US
Assignee:
The University of Iowa Research Foundation - Iowa City IA
International Classification:
C12Q 1/68
US Classification:
435183, 435325, 435456
Abstract:
The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human NGVN protein disclosed herein is 731 amino acids in length and is coded for by a gene spanning 17 exons. Homologs have been identified in mouse, rat, zebrafish. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
Bardet-Biedl Susceptibility Gene And Uses Thereof
US Patent:
7332591, Feb 19, 2008
Filed:
Dec 21, 2004
Appl. No.:
11/019081
Inventors:
Val C. Sheffield - Iowa City IA, US
Edwin Stone - Iowa City IA, US
Thomas Casavant - Iowa City IA, US
Terry Braun - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US
Thomas Casavant - Iowa City IA, US
Terry Braun - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Assignee:
The University of Iowa Research Foundation - Iowa City IA
International Classification:
C07H 21/04
US Classification:
536 231, 536 235, 536 241
Abstract:
The present invention relates to the designation of ADP-ribosylation factor-like 6 as the BBS3 gene, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
Diagnostics Based On A Glaucoma Causing Gene
US Patent:
5916778, Jun 29, 1999
Filed:
Apr 28, 1994
Appl. No.:
8/234218
Inventors:
Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C12P 1934, C12Q 168, C07H 2104
US Classification:
435 912
Abstract:
Methods and compositions for glaucoma diagnostics are disclosed.
Glaucoma Compositions
US Patent:
6271026, Aug 7, 2001
Filed:
Mar 21, 1997
Appl. No.:
8/822999
Inventors:
Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Assignee:
The University of Iowa Research Foundation - Iowa City IA
International Classification:
C12N 500, C12N 502, C12N 1500, C12N 1563
US Classification:
435325
Abstract:
Glaucoma compositions comprising the GLC1A gene are disclosed.