YOSEF KRESPI, M.D.
Medical Practice at 59 St, New York, NY

2010022, Sep 9, 2010

Mar 3, 2010

12/716561

Yosef KRESPI - New York NY, US
Victor Z. Kizhner - New York NY, US

A61B 17/00, A61M 37/00, A61B 18/18

604506, 128898, 606 2, 606108

A method for sinus surgery includes piercing first and second access openings into the anatomy of a human subject to access an inaccessible sinus site for cooperatively manipulating respective first and second surgical instruments inserted through the openings. One instrument, for example an endoscope, can permit viewing of the sinus site while the other instrument is manipulated to effect a treatment at the sinus site. The maxillary and other sinuses can be accessed and anti-inflammatory and other treatments can be applied. Systems and instruments for performing such sinus surgery methods are also disclosed.

2010007, Mar 25, 2010

Jun 8, 2009

12/480281

Yosef Krespi - New York NY, US
Ashutosh Kacker - New York NY, US

A61N 5/06

607 88

Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treatment procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as , by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.

2010016, Jun 24, 2010

Dec 18, 2009

12/642021

Yosef KRESPI - New York NY, US

A61B 17/22, A61B 18/26, A61M 37/00

601 15, 606128, 606 25, 604 20

A two-step mammalian biofilm treatment process can have a first step of disrupting or dispersing an undesired biofilm present at a treatment site in or on a mammalian host by suitable mechanical action for example, by applying irrigation fluid, sonic or other vibration, a mechanical instrument or laser-generated mechanical shockwaves to the biofilm. The treatment can also have a second step comprising applying an antimicrobial treatment to the mammalian host to control possible infection related to biofilm dispersed in the first step or to residual biofilm at the treatment site. Usefully, the second step can be performed within a limited time period after the first step. The process can also include additional steps The antimicrobial treatment can employ light or an antibiotic material. Included are implants cleaned of biofilm by a described process.

2009001, Jan 15, 2009

Sep 16, 2008

12/211295

Yosef KRESPI - New York NY, US
Ashutosh KACKER - New York NY, US

VALAM CORPORATION - New York NY

A61N 5/06

604 20, 607 88

Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.

2010016, Jun 24, 2010

Dec 18, 2009

12/642192

Yosef KRESPI - New York NY, US

A61B 18/24, A61B 17/22

606 7, 606128

A process and instruments for diminishing an undesired endoluminal structure present at a treatment site in a mammalian treatment subject. The endoluminal can be or include a vascular occlusion, a biofilm or another undesired biological structure. The process can include applying mechanical shockwaves to the endoluminal structure and the endoluminal structure absorbing the applied mechanical shockwaves and becoming diminished, dispersed or weakened. The shockwaves can be generated by pulsed laser energy delivered to an ionizable target via an optical fiber.

2011002, Jan 27, 2011

Jul 21, 2010

12/840397

Yosef Krespi - New York NY, US
Victor Z. Kizhner - New York NY, US

A61N 5/06

604 20

Method for treating chronic rhinosinusitis in a human patient. In the method a photosensitizing agent such as indocyanine green can be applied to color a nasal or sinal treatment site harboring infectious microorganisms. The photosensitizing agent can have an energy absorption peak in a near infrared wavelength region of the electromagnetic spectrum. The method can also include applying light energy from a laser source at a near infrared red wavelength or wavelengths to the colored treatment site, for a duration sufficient to control the microorganisms. Apparatus for performing the method is also disclosed.

2004016, Aug 26, 2004

Oct 23, 2003

10/692054

Peter Costantino - Armonk NY, US
Craig Friedman - Westport CT, US
Arindam Datta - Hillsborough NJ, US
Maybelle Jordan - Potomac MD, US
Yosef Krespi - New York NY, US
Daniel Klempner - Bloomfield MI, US
Ian Askill - Colorado Springs CO, US

A61F002/06

623/001100, 623/001110, 623/001440

An aneurysm treatment device for in situ treatment of aneurysms comprising a collapsible member having a first shape wherein the first shape is an expanded geometric configuration, and a second shape, wherein the second shape is a collapsed configuration that is loadable into a catheter. The aneurysm treatment device is capable of returning to the first shape in the lumen of an aneurysm. Some aneurysm treatment devices comprise a spreadable portion and a projecting portion integral with the spreadable portion. The spreadable portion is capable of resting against and supporting an inner wall of an aneurysm, the projecting portion is capable of being gripped by a surgeon to facilitate insertion and positioning of the device. Other devices have relatively simple shapes and can be implanted to a site as a plurality. Treatment methods are also disclosed.

5460626, Oct 24, 1995

Apr 6, 1994

8/223986

Yosef P. Krespi - New York NY

Laser Industries, Ltd. - Tel-Aviv

A61B 126

606 1

An apparatus for and a method of removing smoke and vaporized tissue from a patient's mouth and controlling a patient's tongue through use of a hollow tongue blade coupled to a pneumatic evacuation device which can be used in conjunction with a pharyngeal handpiece during laser applications.