Yale S Arkel
Medical Practice in Westfield, NJ
License number
New Jersey 25MA02093500
Issued Date
Nov 5, 1966
Expiration Date
Jun 30, 2013
Category
Medical Examiners
Type
Medical Doctor
Address
Address
Westfield, NJ
Professional information
Factor V Ratio Blood Test For Susceptibility To Thromboembolism
US Patent:
5766869, Jun 16, 1998
Filed:
Nov 27, 1996
Appl. No.:
8/757926
Inventors:
Yale S. Arkel - Westfield NJ
Dehui Wayne Ku - Mt. Laurel NJ
Dehui Wayne Ku - Mt. Laurel NJ
Assignee:
AHS Hospital Corp. - Summit NJ
International Classification:
C12Q 156, C12Q 137, G01N 3353
US Classification:
435 13
Abstract:
The disclosed Factor V Ratio (FVR) screening blood assay (read as "factor five ratio") and kits for the conduct thereof, identify individuals that possess a specific genetic defect, known as the Factor V Leiden defect, or other genetic or acquired Factor V defect, that makes those individuals susceptible to venous thromboembolism. In this test the Factor V activity of a blood plasma sample exposed to activated Protein C (APC) is compared to the Factor V activity of a similar sample in the absence of APC, after both samples had been treated with an activating agent. The ratio between the Factor V activity level without APC and the Factor V activity level with APC, identifies individuals at risk of a thrombotic disorder due to a Factor V defect and differentiates between individuals with a heterozygous defect and individuals with a homozygous defect.