YALE S ARKEL
Medical Practice in Westfield, NJ
License number
New Jersey 25MS00005600
Issued Date
Nov 1, 2000
Expiration Date
Dec 31, 2011
Category
Medical Examiners
Type
Bioanalytical Lab Dir - Spec
Address
Address
Westfield, NJ
Professional information
Factor V Ratio Blood Test For Susceptibility To Thromboembolism
US Patent:
5766869, Jun 16, 1998
Filed:
Nov 27, 1996
Appl. No.:
8/757926
Inventors:
Yale S. Arkel - Westfield NJ
Dehui Wayne Ku - Mt. Laurel NJ
Dehui Wayne Ku - Mt. Laurel NJ
Assignee:
AHS Hospital Corp. - Summit NJ
International Classification:
C12Q 156, C12Q 137, G01N 3353
US Classification:
435 13
Abstract:
The disclosed Factor V Ratio (FVR) screening blood assay (read as "factor five ratio") and kits for the conduct thereof, identify individuals that possess a specific genetic defect, known as the Factor V Leiden defect, or other genetic or acquired Factor V defect, that makes those individuals susceptible to venous thromboembolism. In this test the Factor V activity of a blood plasma sample exposed to activated Protein C (APC) is compared to the Factor V activity of a similar sample in the absence of APC, after both samples had been treated with an activating agent. The ratio between the Factor V activity level without APC and the Factor V activity level with APC, identifies individuals at risk of a thrombotic disorder due to a Factor V defect and differentiates between individuals with a heterozygous defect and individuals with a homozygous defect.