WILLIAM MICHAEL MCGUIRE
Electrician at Laguna Rd, San Antonio, TX

5188964, Feb 23, 1993

Apr 12, 1990

7/509377

William L. McGuire - San Antonio TX
Atul K. Tandon - San Antonio TX
Gary M. Clark - San Antonio TX
Gary C. Chamness - San Antonio TX

Board of Regents, The University of Texas System - Austin TX

G01N 3348

436 64

The invention relates to a method of predicting disease-free survival in cancer patients by relating the number and amount of stress response proteins in the cancer tissue to the probability of tumor recurrence. Particular heat shock/stress response proteins useful in the determination of tumor recurrence are the stress response proteins, hsp70, hsp90, hsp27, and glucose regulated protein grp94. Specific levels of the stress response proteins are identified, above which the probability of tumor recurrence is highly signficant. Kit methods are disclosed which could enable determination of the stress proteins by an antibody assay.

5862304, Jan 19, 1999

Oct 31, 1990

7/607120

Peter M. Ravdin - San Antonio TX
William L. McGuire - San Antonio TX
Gary M. Clark - San Antonio TX

Board of Regents, The University of Texas System - Austin TX

G06F 1518

395 22

A method is presented for evaluating data to predict the future occurrence of a medical condition that is presently clinically occult or which has not yet occurred. Specifically, the method uses a neural network to analyze and interpret DNA flow cytometric histograms. A first set of DNA histograms taken from tumors from patients having known relapse rates are used to train the neural network, an then the trained network is applied to predict the relapse rates of patients using DNA histograms of tumors from those patients. Prognosis according to this method can be performed using only diploid histograms, using only aneuploid histograms, or using a combination of diploid and aneuploid histograms.

4968603, Nov 6, 1990

Dec 31, 1986

6/948265

Dennis J. Slamon - Woodland Hills CA
William L. McGuire - San Antonio TX

The Regents of the University of California - Berkeley CA

C12Q 168, G01N 5300, G01N 3300

435 6

Amplification of the HER-2/neu oncogene is related to the status of neoplastic diseases, particularly breast and ovarian adenocarcinomas. The presence of multiple gene copies in tumor cells indicates that the disease is more likely to spread beyond the primary tumor site, and that the disease therefore may require more aggressive treatment than might otherwise be indicated by other diagnostic factors. In particular, the degree of gene amplification appears to provide greater prognostic utility than either the estrogen receptor or the progesterone receptor, and provides utility equal to that of the determination of lymph node status. The information provided by the gene amplification test, however, is not duplicative with the determination of lymph node status and the two tests together provide greatly improved prognostic utility.