DR. VINCENT M MONNIER, MD
Medical Practice at Cornell Rd, Cleveland, OH
License number
Ohio 35.051006
Category
Medical Practice
Type
Research Study
Address
Address
2103 Cornell Rd, Cleveland, OH 44106
Phone
(216) 368-6613
(216) 368-1357 (Fax)
(216) 548-6580
(216) 368-1357 (Fax)
(216) 548-6580
Personal information
See more information about VINCENT M MONNIER at radaris.comName
Address
Phone
Cleveland, OH
16300 Aldersyde Dr, Shaker Heights, OH 44120
Professional information
Dr. Vincent M Monnier, Cleveland OH - MD (Doctor of Medicine)
Specialties:
Clinical Pathology
Address:
2103 Cornell Rd, Cleveland 44106
Certifications:
Clinical Pathology, 1985
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of Basel / Medical Faculty
University Hospitals Of Cleveland
University of Basel / Medical Faculty
University Hospitals Of Cleveland
Imidazopyridinium Compound And Processes For Isolating, Identifying, And Chemically Synthesizing Same
US Patent:
5374712, Dec 20, 1994
Filed:
Jun 16, 1992
Appl. No.:
7/897987
Inventors:
Vincent M. Monnier - Shaker Heights OH
David R. Sell - Cleveland Heights OH
David R. Sell - Cleveland Heights OH
Assignee:
Case Western Reserve University - Cleveland OH
International Classification:
C07H 1702, C07H 1904
US Classification:
536 173
Abstract:
The present invention is directed to a novel imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar. The novel imidazo [4,5b] pyridinium compound, referred to as "pentosidine", was isolated from proteineous tissue undergoing advanced glycosylation and is believed to be one of the principal products involved in the nonenzymatic browning and/or aging of proteins. Assaying for the pentosidine molecule makes it possible to assess the degree of aging of proteins in vivo as mediated by pentose induced crosslinking and modulated by disease such as diabetes and nephropathy. In addition, the pentosidine molecule may be utilized through the production of monoclonal antibodies thereto and/or the preparation of test kits, etc. for diagnostic, as well as therapeutic purposes (i. e. development of agents which inhibit the non-enzymatic browning reaction, etc. ).
Process For Assessing The Biological Age Of A Tissue
US Patent:
5480807, Jan 2, 1996
Filed:
Oct 28, 1994
Appl. No.:
8/331276
Inventors:
Vincent M. Monnier - Shaker Heights OH
David R. Sell - Cleveland Heights OH
David R. Sell - Cleveland Heights OH
Assignee:
Case Western Reserve University - Cleveland OH
International Classification:
G01N 33483
US Classification:
436 86
Abstract:
The present invention is directed to use of an imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar for assessing the biological age of a tissue.