THOMAS T AOKI, MD
Osteopathic Medicine at V St, Sacramento, CA

6613342, Sep 2, 2003

Jun 15, 2001

09/881826

Thomas T. Aoki - Sacramento CA 95825

A61F 1300

424422, 424400, 604175, 6048911, 6048921

The present invention is a system and method capable of improving the entire metabolic process and through its multiplicity of effects on neurovascular reactivity, intraglomerular pressure and hemodynamics, arresting the progression of overt diabetic nephropathy, improving intraglomerular hemodynamics, and thus arresting the progression of diabetic nephropathy and therefore reducing the risk of development of End Stage Renal Disease. The current system and method is for the treatment of kidney disease using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve the slowing, stopping or reversing of kidney disease in both diabetic and non-diabetic patient.

6821527, Nov 23, 2004

Mar 19, 2003

10/393424

Thomas T. Aoki - Sacramento CA 95825

A61F 202

424422, 424400, 424423

The present invention is a system capable of improving the entire metabolic process and through its multiplicity of effects on neurovascular reactivity, intraglomerular pressure and hemodynamics, arresting the progression of overt diabetic nephropathy, improving intraglomerular hemodynamics, and thus arresting the progression of diabetic nephropathy and therefore reducing the risk of development of End Stage Renal Disease. The current system is for the treatment of kidney disease using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve the slowing, stopping or reversing of kidney disease in both diabetic and non-diabetic patients.

6613736, Sep 2, 2003

Jun 15, 2001

09/881779

Thomas T. Aoki - Sacramento CA 95825

A61K 3726

514 4, 514 3, 514 8, 530849, 424 145

The present invention is a system and method capable of increasing retinal and neural glucose oxidation by enhancing pyruvate dehydrogenase activity and therefore treats retinopathy and central nervous system disorders in both diabetic and non-diabetic patients. The current invention is a system and method of the treating of eye and nerve diseases using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in retinal and neural glucose oxidation by enhancing pryuvate dehydrogenase activity, therefore treating retinopathy and central nervous system disorders in both diabetic and non-diabetic patients.

7682351, Mar 23, 2010

Dec 17, 2003

10/738897

Thomas T. Aoki - Sacramento CA, US

A61M 31/00

604504

The present invention is a method for delivering insulin to a subject to improve impaired hepatic glucose processing. The method delivers a series of pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that the hepatic processing of glucose is restored in the subject. In subjects whose hepatic glucose processing has been restored there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more directly as a result of improved hepatic glucose processing.

4826810, May 2, 1989

Mar 19, 1987

7/027852

Thomas T. Aoki - Sacramento CA

A61K 3726

514 3

A system and method for treating an animal subject having predetermined body tissues characterized by abnormal or impaired dietary fuel processing capabilities. A dietary fuel of preselected type and quantity is administered to the subject to produce in the blood supply to these body tissues a substantially elevated carbohydrate concentration during a time period following such administration. During at least a portion of the time period of such elevated carbohydrate concentration, insulin is injected into the subject in accordance with a prearranged insulin concentration versus time function. This function is independent of the magnitude of the carbohydrate concentration in the blood stream, i. e. the carbohydrate concentration does not have to be measured since it is not used to control the insulin injection. The insulin injection function produces a rapid increase in the free insulin concentration in the blood supply to the involved body tissues and is preferably a prearranged series of spaced insulin pulses that produce a series of peaks in the free insulin concentration in the blood supply to the target tissues and a continuously rising interpeak value of free insulin concentration.

2014004, Feb 13, 2014

Mar 22, 2012

13/261734

Thomas T. Aoki - Sacramento CA, US

A61K 38/28

530303

Metabolic Activation Therapy (MAT®) is a procedure which uses intravenous insulin pulses administered with oral glucose to deliver an insulin treatment regimen that improves the biochemistry and physiology of diabetic and non-diabetic individuals. If implemented preoperatively to patients with a history of hyperglycemia who undergo surgical and other stress inducing procedures, including those requiring hospitalization, postoperative glycemic control is improved and the insulin required during and after the operation is decreased with no increase in incidents of hypoglycemia. If implemented in patients not previously known to have diabetes but who are at high risk for becoming hyperglycemic in response to said surgical/medical procedures known to be physiologically stressful, it results in increased insulin sensitivity, lower circulating glucose levels post procedure, and shorter length of hospital stay. At the attending physician's discretion, patients already receiving MAT® treatment on a weekly or bi-weekly basis may not require any additional treatment prior to undergoing surgical or other stress inducing medical procedures.

2006012, Jun 8, 2006

Dec 8, 2004

11/007390

Thomas Aoki - Sacramento CA, US

A61K 38/28, A61B 5/00

514003000, 600365000

The present invention is a method for delivering insulin to a subject to improve impaired total body tissue glucose processing. The method delivers one or more pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The number of pulses, the amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that total body tissue processing of glucose is restored in the subject. In subjects whose total body tissue glucose processing has been restored there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more directly as a result of improved total body tissue glucose processing.

2006012, Jun 8, 2006

Dec 8, 2004

11/006863

Thomas Aoki - Sacramento CA, US

A61K 38/28, A61B 5/00

514003000, 600365000

The present invention is a system for delivering insulin to a subject to improve impaired total body tissue glucose processing. The system delivers one or more pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The number of pulses, the amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that total body tissue processing of glucose is restored in the subject. In subjects whose total body tissue glucose processing has been restored, there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more primarily and directly as a result of improved total body tissue glucose processing.

6967191, Nov 22, 2005

Mar 19, 2003

10/393273

Thomas T. Aoki - Sacramento CA, US

A61K037/26

514 4, 514 3

The present invention is a system capable of increasing retinal and neural glucose oxidation by enhancing pyruvate dehydrogenase activity and therefore treats retinopathy and central nervous system disorders in both diabetic and non-diabetic patients. The current invention is a system of the treating of eye and nerve diseases using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in retinal and neural glucose oxidation by enhancing pryuvate dehydrogenase activity, therefore treating retinopathy and central nervous system disorders in both diabetic and non-diabetic patients.