Inventors:
Henry Blair - Boston MA, US
Thomas Beck - Concord MA, US
Robert C. Ladner - Ijamsville MD, US
Assignee:
DYAX CORP. - Cambridge MA
International Classification:
A61K 38/16, A61P 7/00
Abstract:
Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.