Inventors:
Bryan T. Oronsky - Los Altos Hills CA, US
Susan Knox - Stanford CA, US
Jan Scicinski - Saratoga CA, US
Shoucheng Ning - Santa Clara CA, US
International Classification:
A61K 31/397, A61K 31/4468, A61K 31/12, A61K 31/16, A61K 31/04, A61P 35/02, A61K 31/445, A61K 31/255, A61K 31/22, A61K 31/40, A61P 35/00
US Classification:
51421017, 514423, 514315, 514676, 51421001, 514426, 514628, 514517, 514518, 514550, 514742, 514740
Abstract:
The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.