Inventors:
Robert J. Schneider - New York NY, US
Sumayah Jamal - New York NY, US
Assignee:
New York University - New York NY
International Classification:
A61K 38/00, A61K 39/395, A61P 35/00
US Classification:
4241431, 4241551, 514 133, 514 161, 514 192, 514 193, 514 194, 435 723
Abstract:
The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically, the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation.