Inventors:
Benjamin Auspitz - Cambridge MA, US
Bradley Brasher - Natick MA, US
Todd Chappell - Boston MA, US
Michael Frank - Boston MA, US
Daniel Grau - Arlington MA, US
Seth Lederman - New York NY, US
Palaniyandi Manivasakam - West Roxbury MA, US
Seth Orlow - New York NY, US
Noah Sachs - South Boston MA, US
Brendan Smith - Somerville MA, US
International Classification:
A61K 8/49, A61K 38/13, A61K 31/4745, A61K 31/385, A61K 31/522, A61K 31/4178
US Classification:
424059000, 514011000, 514183000, 514263320, 514291000, 514397000, 514471000, 424641000
Abstract:
The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.