Inventors:
Drew Tortoriello - Jersey City NJ, US
Stuart P Weisberg - New York NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 38/28, A61K 38/08, A61K 38/06, A61K 38/07, A61K 31/4015, A61K 31/353, A61K 31/7048, A61K 31/4995, A61K 38/16, A61K 31/12, A61K 31/195, A61K 31/407, A61K 31/18, A61K 38/10, A61K 31/192, A61P 5/50, A61P 3/10, A61P 29/00
US Classification:
514 67, 514 218, 514 219, 514425, 514456, 514 27, 514250, 514 212, 514679, 514562, 514421, 514604, 514 215, 514569
Abstract:
Methods of modulating chronic low-grade inflammation are provided. More particularly, methods of treating diabetes, such as for example, type-2 diabetes mellitus, in a mammal by administering an effective amount of a selective proteasome inhibitor are provided. Also provided are unit dosage forms of such inhibitors.