Inventors:
Pamela Flood - Closter NJ, US
Steven Shafer - Palo Alto CA, US
Assignee:
The Trustees of Columbia University - New York NY
International Classification:
A61K 31/485, A61K 31/4439, A61K 31/445, A61K 31/22, A61K 31/14
US Classification:
514282000, 514343000, 514546000, 514642000, 514317000
Abstract:
This invention provides two methods for reducing, or inhibiting the onset of, pain in a subject. The first method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist, and (b) an opioid receptor agonist; wherein the ratio of nicotinic receptor agonist to opioid receptor agonist administered to the subject is less than 3:4 and greater than 1:100. The second method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist at a rate of less than 3 mg per three hour period; and (b) an opioid receptor agonist at a rate of less than 4 mg per three hour period. This invention also provides two compositions, a transdermal patch, and an article of manufacture for practicing the instant methods.