Inventors:
Stephen F. Vatner - Barnegat Light NJ, US
Dorothy E. Vatner - Barnegat Light NJ, US
Junichi Sadoshima - Berkeley Heights NJ, US
Jayashree Pain - Livingston NJ, US
Assignee:
University of Medicine and Dentistry of New Jersey - Somerset NJ
International Classification:
C12N 5/20, C07K 16/40, C07H 7/00
Abstract:
The invention relates to compositions and methods for diagnosing and treating cardiac conditions and neurodegenerative diseases using antibodies which specifically recognize and bind to the adenylyl cyclase 5 isoform in the heart and brain. These antibodies demonstrate high specificity to the AC5 isoform and do not cross react to any other AC5 isoform. The invention further relates to methods of delivery of drugs to the site of injured tissue using the antibodies of the present invention.