SHAUN COUGHLIN, M.D., PH.D.
Osteopathic Medicine at Turtle Rock Ct, Tiburon, CA
License number
California G52403
Category
Osteopathic Medicine
Type
Cardiovascular Disease
License number
California 52746
Category
Osteopathic Medicine
Type
Cardiovascular Disease
Address
Address
2 Turtle Rock Ct, Tiburon, CA 94920
Phone
(415) 435-5803
Organization information
See more information about SHAUN COUGHLIN at bizstanding.comShaun Coughlin MD,PHD
2 Turtle Rock Ct, Belvedere Tiburon, CA 94920
Industry:
Internist
Phone:
(415) 435-5803 (Phone)
Shaun Robert Coughlin
Professional information
Mcp-1 Receptor Antibodies
US Patent:
6730301, May 4, 2004
Filed:
Jul 25, 2000
Appl. No.:
09/625573
Inventors:
Israel R. Charo - San Francisco CA
Shaun R. Coughlin - Tiburon CA
Shaun R. Coughlin - Tiburon CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 39395
US Classification:
4241391, 4241301, 435326, 530386, 5303879, 53038822, 5303891, 5303913
Abstract:
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
Modified Factor Vii Polypeptides And Uses Thereof
US Patent:
2009009, Apr 16, 2009
Filed:
Apr 11, 2008
Appl. No.:
12/082662
Inventors:
Edwin L. Madison - San Francisco CA, US
Christopher Thanos - San Francisco CA, US
Sandra Waugh Ruggles - Sunnyvale CA, US
Shaun Coughlin - Tiburon CA, US
Christopher Thanos - San Francisco CA, US
Sandra Waugh Ruggles - Sunnyvale CA, US
Shaun Coughlin - Tiburon CA, US
International Classification:
A61K 38/48, C12N 9/50, C12N 15/11, C12N 15/00, C12N 5/06, C12N 1/19
US Classification:
424 9464, 435219, 536 232, 4353201, 435325, 4352542, 43525423, 435358, 435352
Abstract:
Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
Mammalian Monocyte Chemoattractant Protein Receptors And Assays Using Them
US Patent:
5707815, Jan 13, 1998
Filed:
May 25, 1995
Appl. No.:
8/450393
Inventors:
Israel F. Charo - Lafayette CA
Shaun R. Coughlin - Tiburon CA
Shaun R. Coughlin - Tiburon CA
Assignee:
Regents of the University of California - Oakland CA
International Classification:
C07K 14705, G01N 3353, G01N 33566
US Classification:
435 72
Abstract:
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
Methods And Compositions For Regulating Cell Cycle Progression
US Patent:
6183961, Feb 6, 2001
Filed:
Sep 18, 1998
Appl. No.:
9/156316
Inventors:
Harold S. Bernstein - San Francisco CA
Shaun R. Coughlin - Tiburon CA
Shaun R. Coughlin - Tiburon CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 168, C07H 2104, C12N 1563
US Classification:
435 6
Abstract:
Method and compositions for regulating cell cycle progression are disclosed. Compositions include nucleic acids comprising a human Cdc5 gene, antisense gene and fragments thereof and a human Cdc5 protein and polypeptide fragments thereof polypeptide. The compositions can be used in a method to treat diseases relating to a cell cycle defect.
Recombinant Mammalian Monocyte Chemotactic Protein-1 (Mcp-1) Receptors (Mcp-1R, Ccr-2)
US Patent:
6132987, Oct 17, 2000
Filed:
May 25, 1995
Appl. No.:
8/446669
Inventors:
Israel F. Charo - Lafayette CA
Shaun R. Coughlin - Tiburon CA
Shaun R. Coughlin - Tiburon CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 1512, C07K 14715, G01N 3353
US Classification:
435 691
Abstract:
DNAs encoding receptors for the chemokine, Monocyte Chemotactic Protein-1 (MCP-1), are disclosed. Recombinant reagents and methods for expressing the DNAs are also provided. Exemplary receptor proteins are MCP-1RA and MCP-1RB, which correspond to alternatively spliced transcripts of the human MCP-1R gene. The receptor proteins of the invention are useful in assays to identify agonists and antagonists of MCP-1.
Mammalian Monocyte Chemoattractant Protein Receptors
US Patent:
2004022, Nov 11, 2004
Filed:
Mar 1, 2004
Appl. No.:
10/791166
Inventors:
Israel Charo - San Francisco CA, US
Shaun Coughlin - Tiburon CA, US
Shaun Coughlin - Tiburon CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K039/395, C07K014/705
US Classification:
424/145100, 530/350000
Abstract:
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
Methods And Compositions For Regulating Cell Cycle Progression
US Patent:
2002012, Sep 12, 2002
Filed:
Jan 8, 2001
Appl. No.:
09/757049
Inventors:
Harold Bernstein - San Francisco CA, US
Shaun Coughlin - Tiburon CA, US
Shaun Coughlin - Tiburon CA, US
International Classification:
A61K039/00, A61K039/38, C07K001/00, C07K014/00, C07K017/00, C12N001/20
US Classification:
435/252300, 424/184100, 530/350000
Abstract:
Method and compositions for regulating cell cycle progression are disclosed. Compositions include nucleic acids comprising a human Cdc5 gene, antisense gene and fragments thereof and a human Cdc5 protein and polypeptide fragments thereof polypeptide. The consensus DNA binding site for hCdc5 has been described.
Methods Of Screening For Antagonists Of Mammalian Monocyte Chemoattractant Protein Receptors
US Patent:
7803560, Sep 28, 2010
Filed:
Feb 5, 2007
Appl. No.:
11/702711
Inventors:
Israel F. Charo - San Francisco CA, US
Shaun R. Coughlin - Tiburon CA, US
Shaun R. Coughlin - Tiburon CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 33/566, G01N 33/58, G01N 33/68
US Classification:
435 72, 435 691
Abstract:
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
Method For Discovery Of Peptide Agonists
US Patent:
5925529, Jul 20, 1999
Filed:
Jun 7, 1995
Appl. No.:
8/483506
Inventors:
Shaun R. Coughlin - Tiburon CA
Ji Chen - San Francisco CA
Harold Bernstein - San Francisco CA
Maki Ishii - Kyoto, JP
Ling Wang - San Francisco CA
Mian Chen - San Francisco CA
Ji Chen - San Francisco CA
Harold Bernstein - San Francisco CA
Maki Ishii - Kyoto, JP
Ling Wang - San Francisco CA
Mian Chen - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 3353, G01N 33543
US Classification:
435 72
Abstract:
This invention relates to peptide ligand discovery and is particularly directed to a method for the discovery of agonists for membrane bound receptors. The inventive detection system involves the use of a "tethered" ligand for probing receptor binding. The general detection system includes a membrane, a membrane bound receptor, and a chimeric ligand presenting molecule. This chimeric protein forms the tethered ligand and in turn includes a membrane domain, a linker domain, a ligand domain, and a cleavable terminal domain. The "ligands" of the system are exposed by the addition of a specific peptidase that cleaves at the designated sequence. The sequence of the ligand that produces signal as a result of the interaction between the agonist and receptor can be then be isolated using sib selection.
Mcp-1 Receptor Antibodies
US Patent:
7105641, Sep 12, 2006
Filed:
Mar 1, 2004
Appl. No.:
10/791592
Inventors:
Israel R. Charo - San Francisco CA, US
Shaun R. Coughlin - Tiburon CA, US
Shaun R. Coughlin - Tiburon CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07K 16/28, A61K 39/395, C12P 21/00
US Classification:
5303879, 5303891, 4241391
Abstract:
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.