Inventors:
Gregory Bell - Tiburon CA, US
Sarah Walter - Redwood City CA, US
Felix Karim - Walnut Creek CA, US
International Classification:
A61K 38/00, C07K 14/00, C07K 7/00, A61P 19/00
US Classification:
514 12, 514 18, 514 17, 514 16, 514 15, 514 14, 514 13, 530330, 530329, 530328, 530327, 530326, 530325, 530324
Abstract:
The present invention provides methods and kits for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders. In particular, methods for lowering serum PTH and serum calcium using polycationic calcium modulator peptides are provided. The calcium modulator peptides can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.