Inventors:
Andrew R. Blight - Mahopac NY, US
Lawrence Maranucci - White Plains NY, US
Ron Cohen - Irvington NY, US
International Classification:
A61K 49/00, A61P 25/00, A61P 21/00, A61K 31/4409
Abstract:
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.