Inventors:
Federica Del Monte - Boston MA, US
Roger J. Hajjar - New York NY, US
Fabrice Prunier - Angers, FR
International Classification:
A61K 31/7088, A61K 31/7105, A61K 31/711
Abstract:
The present invention provides methods and materials for treating heart disorders, including heart failure and arrhythmia, by enhancing SERCA2a activity. Heart cells in a subject can be treated, for example, by introducing, into the heart of the subject, an adeno-associated virus subtype 6 (AAV6) viral delivery system that includes a functional nucleic acid encoding SERCA2a. For example, the functional nucleic acid encodes a non-viral therapeutic protein, thereby treating the subject.