Inventors:
Anna M. Wu - Sherman Oaks CA, US
Robert E. Reiter - Los Angeles CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 49/00, C07K 16/30, A61K 49/04, G01N 33/574, A61K 39/395
US Classification:
424 91, 5303873, 424 149, 424 94, 435 723, 4241331
Abstract:
The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate, bladder, and pancreatic cancer. Methods are provided for the use of the compositions of the invention for the treatment of cancer, diagnosis of cancer, to provide a prognosis of cancer progression, and for cancer imaging.