Inventors:
Michael Girardi - Madison CT, US
Robert Tigelaar - New Haven CT, US
Michael Sherling - Brookline MA, US
John Shires - Stone Mountain GA, US
Adrian Hayday - Kent, GB
Efatathios Theodoridis - London, GB
Assignee:
Yale University Office Of Cooperstive Research - New Haven CT
King's College London - London
International Classification:
A61K 38/22
Abstract:
The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4polypeptide variant. The invention also provides a method of promoting wound healing in a subject comprising administering to the subject a composition comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4polypeptide variant. The invention also relates to methods of treating the above mentioned conditions in a subject comprising administering to the subject a nucleic acid encoding a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant. The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.