Inventors:
Michael C. Dean - Frederick MD, US
Heidi Eve Hahn - Goettingen, DE
Carol Wicking - Auchenflower, AU
Jeffrey Christiansen - Yeronga, AU
Peter G. Zaphiropoulos - Tullinge, SE
Mae R. Gailani - Guilford CT, US
Susan M. Shanley - Norman Park, AU
Abirami Chidambaram - Frederick MD, US
Igor Vorechovsky - Huddinge, SE
Erika Holmberg-Lindstrom - Taby, SE
Anne B. Unden - Djursholm, SE
Susan A. Gilles - Newfarm, AU
Kylie Negus - Queenslopes, AU
Ian McLeod Smyth - Fig Tree Pocket, AU
Carol L. Pressman - Houston TX, US
David J. Leffell - New Haven CT, US
Bernard Gerrard - Frederick MD, US
Alisa M. Goldstein - Rockville MD, US
Brandon Wainwright - Bardon, AU
Rune C. M. Toftgard - Skarholmen, SE
Georgia Chenevix-Trench - Toowong, AU
Allen E. Bale - Northford CT, US
Assignee:
United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07K 14/47, C12N 15/12, G01N 33/574
US Classification:
530350, 530828, 530842, 435 691, 435 697, 4241851, 4241921, 4242771
Abstract:
This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the patched (ptc) gene.