DR. RICHARD AXEL, M.D.
Medical Practice at 168 St, New York, NY
License number
New York 1194911
Category
Medical Practice
Type
Anatomic Pathology
Address
Address
701 W 168Th St, New York, NY 10032
Phone
(212) 305-6915
Professional information
Richard H Axel, New York NY
Specialties:
Anatomic & Clinical Pathology
Address:
19 Stuyvesant Oval STE 5A, New York 10009
(212) 529-5568 (Phone), (212) 529-1657 (Fax)
(212) 529-5568 (Phone), (212) 529-1657 (Fax)
Languages:
English
Education:
Medical School
Johns Hopkins University / School of Medicine
Graduated: 1971
Johns Hopkins University / School of Medicine
Graduated: 1971
Internal Deletion Mutants Of Soluble T4(Cd4)
US Patent:
5422274, Jun 6, 1995
Filed:
Feb 5, 1992
Appl. No.:
7/830489
Inventors:
Paul J. Maddon - New York NY
Richard Axel - New York NY
Raymond W. Sweet - Bala Cynwyd PA
James Arthos - Ann Arbor MI
Richard Axel - New York NY
Raymond W. Sweet - Bala Cynwyd PA
James Arthos - Ann Arbor MI
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
SmithKline Beckman Corporation - Philadelphia PA
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
C12N 1500, A61K 3900, C07K 300
US Classification:
4353201
Abstract:
This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185.
This invention also provides a method for treating a subject infected with a human immunodeficiency virus.
Processes For Inserting Dna Into Eucaryotic Cells And For Producing Proteinaceous Materials
US Patent:
4634665, Jan 6, 1987
Filed:
Aug 11, 1983
Appl. No.:
6/522408
Inventors:
Richard Axel - New York NY
Michael H. Wigler - Cold Spring Harbor NY
Saul J. Silverstein - Irvington NY
Michael H. Wigler - Cold Spring Harbor NY
Saul J. Silverstein - Irvington NY
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12P 2100, C12N 1500, C12N 500, C12R 191
US Classification:
435 68
Abstract:
The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells with such DNA together with a second DNA which corresponds to a gene coding for a selectable marker.
This invention also concerns processes for producing proteinaceous materials such as insulin, interferon protein, growth hormone and the like which involve cotransforming eucaryotic cells with DNA which codes for these proteinaceous materials, growing the contransformed cells for production of the proteinaceous material and recovering the proteinaceous material so produced.
The invention further relates to processes for inserting into eucaryotic cells a multiplicity of DNA molecules which includes genes coding for desired proteinaceous materials. The insertion of multiple copies of desired genes is accomplished by cotransformation with the desired genes and with amplifiable genes for a dominant selectable marker in the presence of successively higher amounts of an inhibitor.
Chemosensory Gene Family Encoding Gustatory And Olfactory Receptors And Uses Thereof
US Patent:
2011020, Aug 18, 2011
Filed:
Nov 29, 2010
Appl. No.:
12/955750
Inventors:
Richard Axel - New York NY, US
Kristin Scott - New York NY, US
Kristin Scott - New York NY, US
International Classification:
C12P 21/02, C12N 15/63, C07H 21/00, C07H 21/04, C07H 21/02, C12N 5/10, C12N 1/21, C12N 1/19
US Classification:
435 691, 4353201, 536 235, 435325, 435348, 4352523, 4352542
Abstract:
This invention provides an isolated nucleic acid encoding an insect gustatory or odorant receptor. This invention provides a nucleic acid of at least 12 nucleotides capable of specifically hybridizing with a nucleic acid encoding an insect gustatory or odorant receptor. This invention also provides a purified, insect gustatory or odorant receptor. This invention provides an antibody capable of specifically binding to an insect gustatory or odorant receptor. This invention provides a method of identifying a compound capable of specifically binding to, activating, or inhibiting the activity of an insect gustatory or odorant receptor. This invention also provides methods of controlling insect populations.
Dna Encoding The T Cell Surface Protein T4 And Use Of Fragments Of T4 In The Treatment Of Aids
US Patent:
5871913, Feb 16, 1999
Filed:
Jun 5, 1995
Appl. No.:
8/462138
Inventors:
Paul J. Maddon - New York NY
Dan R. Littman - San Francisco CA
Leonard Chess - Scarsdale NY
Richard Axel - New York NY
Robin Weiss - London, GB2
J. Steven McDougal - Atlanta GA
Dan R. Littman - San Francisco CA
Leonard Chess - Scarsdale NY
Richard Axel - New York NY
Robin Weiss - London, GB2
J. Steven McDougal - Atlanta GA
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12Q 168, C07H 2104
US Classification:
435 6
Abstract:
A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4 cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
Method For Assaying Protein-Protein Interaction
US Patent:
2012007, Mar 29, 2012
Filed:
Aug 18, 2011
Appl. No.:
13/212965
Inventors:
Kevin J. LEE - New York NY, US
Richard Axel - New York NY, US
Walter Strapps - San Francisco CA, US
Gilad Barnea - Providence RI, US
Richard Axel - New York NY, US
Walter Strapps - San Francisco CA, US
Gilad Barnea - Providence RI, US
Assignee:
Life Technologies Corporation - Carlsbad CA
International Classification:
C12Q 1/02, C12N 15/62, C12N 15/63, C40B 30/08, C12N 9/96, C12N 5/10, C12Q 1/34, C12N 1/21, C07K 14/00
US Classification:
506 11, 435 29, 43525233, 536 234, 4353201, 530350, 536 232, 435188, 43525231, 4352523, 43525234, 435367, 435357, 435365, 435358, 435353, 435369, 435 18
Abstract:
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
Method For Assaying Protein-Protein Interaction
US Patent:
8017398, Sep 13, 2011
Filed:
Feb 2, 2006
Appl. No.:
11/346759
Inventors:
Kevin J. Lee - New York NY, US
Richard Axel - NY NY, US
Walter Strapps - NY NY, US
Gilad Barnea - NY NY, US
Richard Axel - NY NY, US
Walter Strapps - NY NY, US
Gilad Barnea - NY NY, US
Assignee:
Life Technologies Corporation - Carlsbad CA
The Trustees of Columbia University in the City of New York - New York NY
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 15/09, C12N 15/00, C12N 1/21, C12N 15/85
US Classification:
435455, 4352523, 435325, 435 697
Abstract:
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
Genes Encoding Insect Odorant Receptors And Uses Thereof
US Patent:
7241881, Jul 10, 2007
Filed:
Jun 25, 2002
Appl. No.:
10/183708
Inventors:
Leslie B. Vosshall - New York NY, US
Hubert O. Amrein - Durham NC, US
Richard Axel - New York NY, US
Hubert O. Amrein - Durham NC, US
Richard Axel - New York NY, US
Assignee:
The Trustees of Columbia University in the city of New York - New York NY
International Classification:
C12N 15/12, C07K 14/705
US Classification:
536 235, 435 721, 435 691, 4352523, 4353201
Abstract:
This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention provides an antibody capable of specifically binding to an insect odorant receptor. This invention provides a method for identifying cDNA inserts encoding an insect odorant receptors. This invention provides a method of identifying a compound capable of specifically bind to an insect odorant receptor. This invention also provides a method of identifying a compound capable of activating the activity of an insect odorant receptor.
Method For Assaying Protein—Protein Interaction
US Patent:
7049076, May 23, 2006
Filed:
Jul 9, 2004
Appl. No.:
10/888313
Inventors:
Kevin J. Lee - New York NY, US
Richard Axel - New York NY, US
Walter Strapps - New York NY, US
Gilad Barnea - New York NY, US
Richard Axel - New York NY, US
Walter Strapps - New York NY, US
Gilad Barnea - New York NY, US
Assignee:
Sentigen Biosciences, Inc. - New York NY
The Trustees of Columbia University of the City of New York - New York NY
The Trustees of Columbia University of the City of New York - New York NY
International Classification:
C07H 21/04, C12Q 1/68, G01N 33/53, G01N 33/567, C12N 15/63, C12Q 1/60
US Classification:
435 6, 435 72, 435 721, 4353201, 536 231, 536 234
Abstract:
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
Chemosensory Gene Family Encoding Gustatory And Odorant Receptors And Uses Thereof
US Patent:
2009009, Apr 9, 2009
Filed:
Oct 14, 2008
Appl. No.:
12/287781
Inventors:
Richard Axel - New York NY, US
Kristin Scott - New York NY, US
Kristin Scott - New York NY, US
International Classification:
C12P 21/00, C07H 21/04, C12N 15/63
US Classification:
435 691, 536 235, 4353201
Abstract:
This invention provides an isolated nucleic acid encoding an insect gustatory or odorant receptor. This invention provides a nucleic acid of at least 12 nucleotides capable of specifically hybridizing with a nucleic acid encoding an insect gustatory or odorant receptor. This invention also provides a purified, insect gustatory or odorant receptor. This invention provides an antibody capable of specifically binding to an insect gustatory or odorant receptor. This invention provides a method of identifying a compound capable of specifically binding to, activating, or inhibiting the activity of an insect gustatory or odorant receptor. This invention also provides methods of controlling insect populations.