Inventors:
Michel Sadelain - New York NY, US
Renier Brentjens - New York NY, US
John Maher - London, GB
Assignee:
Sloan Kettering Institute for Cancer Research - New York NY
International Classification:
C12Q001/68, C07H021/04, C12P021/02, C12N005/06, C07K014/705, C07K016/28
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 530/388220, 536/023500
Abstract:
Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 -chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.