Inventors:
Rebecca Bakker-Arkema - Ann Arbor MI, US
Ok Hwang - Ann Arbor MI, US
Sotirios Karathanasis - Carmel IN, US
Diane MacDougall - Ann Arbor MI, US
International Classification:
A61K031/12, A61K031/10, A01N031/14
US Classification:
514/675000, 514/712000, 514/722000
Abstract:
Disclosed are methods of lowering plasma CRP levels, reducing systemic inflammation, and inhibiting proinflammatory cytokine induced CRP production by administering an effective amount of a substituted dialkyl ether, substituted alkyl, substituted aryl-alkyl, substituted dialkyl thioether, substituted dialkyl ketone, substituted-alkyl, or a pharmaceutically acceptable salt of the substituted dialkyl ether, substituted alkyl, substituted aryl-alkyl, substituted dialkyl thioether, substituted dialkyl ketone, or substituted-alkyl or a pharmaceutical composition comprising a substituted dialkyl ether, substituted alkyl, substituted aryl-alkyl, substituted dialkyl thioether, substituted dialkyl ketone, substituted-alkyl.