Inventors:
Charles Shipman - Dexter MI
Mohammad R. Nassiri - Ann Arbor MI
Gordon L. Flynn - Ann Arbor MI
Assignee:
Board of Regents Acting for and on behalf of University of Michigan - Ann Arbor MI
International Classification:
A61K 3144
Abstract:
A process for relieving pain and novel topical compositions for transdermal delivery of a narcotic analgesic comprising the application to mammalian skin of an effective amount of a compound of the formula: ##STR1## or a pharmacologically acceptable acid addition salt thereof, where R is --CH. sub. 2, ##STR2## or --H and R' and R" are C. sub. 1 to C. sub. 6 hydrocarbons or --H, in association with a topical pharmaceutical carrier selected from the group consisting of ointments, lotions, pastes, jellies, gels, creams, sprays, aerosols and the like.