Inventors:
David J. Sugarbaker - Milton MA, US
Raphael Bueno - Brookline MA, US
Assignee:
Brigham & Women's Hospital - Boston MA
International Classification:
C12Q 1/68, C12N 1/21, C07H 21/04, C12N 15/63, C40B 30/04, C12N 5/10, C12N 1/19
US Classification:
435 611, 435 61, 435 612, 435325, 435348, 435358, 435366, 435419, 4352523, 43525233, 4352542, 43525421, 4353201, 506 9, 536 234
Abstract:
The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention.