Inventors:
Susanne M. Gollin - Pittsburgh PA, US
Rahul Atul Parikh - Pittsburgh PA, US
Xin Huang - Menlo Park CA, US
International Classification:
C12Q 1/68, G01N 21/64, A61K 31/713, A61P 35/00, A61K 31/4709, A61K 31/4965, A61K 31/497, C12Q 1/06, A61K 31/7105
US Classification:
514 44 A, 435 611, 435 39, 514 44 R, 514305, 51425506, 51425505
Abstract:
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR/CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and/or chemotherapy who may benefit from ATR/CHEK1 pathway inhibition, as well as methods of treating said patients.