DERIC MINWOO PARK
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD431575
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15217
Professional information
Use Of Phosphatases To Treat Tumors Overexpressing N-Cor
US Patent:
2009001, Jan 15, 2009
Filed:
Feb 6, 2007
Appl. No.:
11/703401
Inventors:
Zhengping Zhuang - Bethesda MD, US
Edward H. Oldfield - Philmont VA, US
Deric M. Park - Pittsburgh PA, US
Irina Lubensky - Potomac MD, US
Jie Li - Gaithersburg MD, US
John S. Kovach - East Setauket NY, US
Edward H. Oldfield - Philmont VA, US
Deric M. Park - Pittsburgh PA, US
Irina Lubensky - Potomac MD, US
Jie Li - Gaithersburg MD, US
John S. Kovach - East Setauket NY, US
International Classification:
A61K 31/496, C12Q 1/02, G01N 33/50, A61P 35/00
US Classification:
51425501, 435 29, 436 86
Abstract:
This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.