Inventors:
Julia A. Kornfield - Pasadena CA, US
Robert H. Grubbs - South Pasadena CA, US
Choon Woo Lee - Pasadana CA, US
Daniel Schwartz - San Francisco CA, US
Phoebe Lin - Durham NC, US
Keith Duncan - San Francisco CA, US
International Classification:
A61K 38/20, A61K 31/522, A61K 31/417, A61K 31/4045, A61K 38/18, A61K 38/02, A61K 31/685, A61K 38/19, A61K 31/7076, A61K 31/265, A61K 31/235, C12Q 1/02, C07C 69/96, A61K 31/27, A61P 27/02
US Classification:
424 852, 51425216, 514399, 514415, 514 81, 514 208, 514 77, 424 851, 514 47, 514512, 514534, 435 29, 558273, 514490
Abstract:
A method of treating an ocular surface disorder in a subject in need of such treatment is provided. The method includes exposing conjunctival tissue of the subject to an effective amount of a vasopermeability agent that increases conjunctival vascular permeability. In some embodiments, the agent is a nitric oxide donor, which may be in a sustained release form. A method of screening a substance for treating an ocular surface disorder is also provided.