DR. PHILIP COFFINO, MD
Osteopathic Medicine in San Francisco, CA
License number
California G24724
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
513 Parnassus Ave Microbiology ROOM S430, San Francisco, CA 94143
Phone
(415) 476-1783
Personal information
See more information about PHILIP COFFINO at radaris.comName
Address
Phone
16 Edgehill Way, San Francisco, CA 94127
1572 Shrader St, San Francisco, CA 94117
5 Burnett Ave N, San Francisco, CA 94131
7 Burnett Ave N, San Francisco, CA 94131
Organization information
See more information about PHILIP COFFINO at bizstanding.comPhilip Coffino MD,PHD
513 Parnassus Ave, San Francisco, CA 94131
Industry:
Internist
Phone:
(415) 476-1783 (Phone)
Philip Coffino
Professional information
See more information about PHILIP COFFINO at trustoria.com
Professor At Ucsf
Professor At Ucsf
Position:
Professor at UCSF
Location:
San Francisco Bay Area
Industry:
Biotechnology
Work:
UCSF
since Jul 1974
-
Professor
Dr. Philip Coffino, San Francisco CA - MD (Doctor of Medicine)
Dr. Philip Coffino, San Francisco CA - MD (Doctor of Medicine)
Specialties:
Clinical Pharmacology
Address:
513 Parnassus Ave, San Francisco 94143
(415) 476-1783 (Phone)
(415) 476-1783 (Phone)
Languages:
English
Education:
Medical School
Albert Einstein College of Medicine of Yeshiva University
Graduated: 1972
Albert Einstein College of Medicine of Yeshiva University
Graduated: 1972
Philip Coffino, San Francisco CA
Philip Coffino, San Francisco CA
Specialties:
Internist
Address:
513 Parnassus Ave, San Francisco, CA 94143
Method For Targeting Degradation Of Intracellular Proteins
Method For Targeting Degradation Of Intracellular Proteins
US Patent:
5866121, Feb 2, 1999
Filed:
Feb 23, 1996
Appl. No.:
8/603575
Inventors:
Philip Coffino - San Francisco CA
Xianqiang Li - Mountain View CA
Xianqiang Li - Mountain View CA
Assignee:
The Regents of The University of California - Oakland CA
International Classification:
A61K 3848, A61K 3851, G01N 3353, C12P 2106
US Classification:
424 9463
Abstract:
A method for selective targeted degradation of intracellular proteins in situ by inducing in cells a production of an agent comprising N-terminal domain as well as a C-terminal domain. The N-terminal domain destabilizes the target protein and directs its degradation when attached to it through the C-terminal domain acting as a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within 97 amino acids corresponding to the N-terminus of protein antizyme.
Method For Targeted Degradation Of Intracellular Proteins In Vivo Or Ex Vivo
Method For Targeted Degradation Of Intracellular Proteins In Vivo Or Ex Vivo
US Patent:
6217864, Apr 17, 2001
Filed:
Feb 2, 1999
Appl. No.:
9/243273
Inventors:
Philip Coffino - San Francisco CA
Xianqiang Li - Palo Alto CA
Xianqiang Li - Palo Alto CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3848, A61K 3851, G01N 3355, C12P 2106
US Classification:
424 9463
Abstract:
A method for in vivo selective targeted degradation of intracellular proteins in situ by inducing in vivo or ex vivo in cells a production of dual-function protein comprising N-terminal domain as well as a C-terminal domain or delivering the dual-function protein. The N-terminal domain of the dual-function protein destabilizes the target protein and directs its degradation when linked to it through a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within the first 97 amino acids corresponding to the N-terminus of protein antizyme.