PHILIP B PATY, MD
Radiology at York Ave, New York, NY

2010014, Jun 10, 2010

Dec 19, 2007

12/520386

Francis Barany - New York NY, US
Yu-Wei Cheng - Forest Hills NY, US
Philip Paty - New York NY, US
Daniel Notterman - Cranbury NJ, US

CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY
SLOAN KETTERING CANCER CENTER - New York NY
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - New Brunswick NJ

A61K 31/27, C12Q 1/68, A61K 31/07, A61K 31/10

514478, 435 6, 514725, 514709

The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.

6534293, Mar 18, 2003

Jan 5, 2000

09/478189

Francis Barany - New York NY
Jianzhao Liu - New York NY
Brian W. Kirk - New York NY
Monib Zirvi - New York NY
Norman P. Gerry - New York NY
Philip B. Paty - New York NY

Cornell Research Foundation, Inc. - Ithaca NY
Sloan-Kettering Institute for Cancer Research - New York NY

C12P 1934

435 912, 435 6, 435 911, 4352871, 4352872, 436 94, 536 231

The present invention is directed to a method of assembling genomic maps of an organisms DNA or portions thereof. A library of an organisms DNA is provided where the individual genomic segments or sequences are found on more than one clone in the library. Representations of the genome are created, and nucleic acid sequence information is generated from the representations. The sequence information is analyzed to determine clone overlap from a representation. The clone overlap and sequence information from different representations is combined to assemble a genomic map of the organism. Once the genomic map is obtained, genomic sequence information from multiple individuals can be applied to the map and compared with one another to identify single nucleotide polymorphisms. These single nucleotide polymorphisms can be detected, and alleles quantified, by conducting (1) a global PCR amplification which creates a genome representation, and (2) a ligation detection reaction process whose ligation products are captured by hybridization to a support.

8367322, Feb 5, 2013

Jul 17, 2002

10/198235

Francis Barany - New York NY, US
Jianzhao Kiu - Boston MA, US
Brian W. Kirk - New York NY, US
Monib Zirvi - Willingboro NJ, US
Norman P. Gerry - Boston MA, US
Philip B. Paty - New York NY, US

Cornell Research Foundation, Inc. - Ithaca NY
Sloan-Kettering Institute for Cancer Research - New York NY

C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04, C07H 21/00

435 61, 435 611, 435 612, 435 911, 435 912

The present invention is directed to a method of assembling genomic maps of an organism's DNA or portions thereof. A library of an organism's DNA is provided where the individual genomic segments or sequences are found on more than one clone in the library. Representations of the genome are created, and nucleic acid sequence information is generated from the representations. The sequence information is analyzed to determine clone overlap from a representation. The clone overlap and sequence information from different representations is combined to assemble a genomic map of the organism. Once the genomic map is obtained, genomic sequence information from multiple individuals can be applied to the map and compared with one another to identify single nucleotide polymorphisms. These single nucleotide polymorphisms can be detected, and alleles quantified, by conducting (1) a global PCR amplification which creates a genome representation, and (2) a ligation detection reaction process whose ligation products are captured by hybridization to a support.

2011025, Oct 20, 2011

Oct 13, 2009

13/123689

Francis Barany - New York NY, US
Owen Parker - Brooklyn NY, US
Manny D. Bacolod - Roosevelt Island NY, US
Sarah F. Giardina - New York NY, US
Yu-wei Cheng - Chicago IL, US
Daniel A. Notterman - Cranbury NJ, US
Gunter S. Schemmann - Princeton NJ, US
Philip B. Paty - New York NY, US
Monib Zirvi - Monmouth Junction NJ, US

CORNELL UNIVERSITY - Ithaca NY
THE TRUSTEES OF PRINCETON UNIVERSITY - Princeton NJ
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH - New York NY
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - New Brunswick NJ

C40B 30/04, C40B 40/06, G01N 33/53, C40B 40/08, C12Q 1/68, G01N 33/566

506 9, 435 61, 435 618, 435 617, 436501, 435 612, 435 611, 435 613, 506 17, 506 16

Closures for containers and methods for using same are provided. In a general embodiment/the present disclosure provides a closure having a top portion (), a bottom portion () and a side portion (), an aperture () extending though the closure, a projection () extending from the closure and at least two rib members () on an interior of the projection. The projection may also include a cover (). In another embodiment, a method for using a closure includes inserting a. spike member into a projection, piercing a membrane that hermetically seals a medical container, pushing rib members within the projection to center the spike member inserted into the projection, and tearing the membrane to create a vent hole in the membrane.