Inventors:
Daniel H. Teitelbaum - Ann Arbor MI, US
Hollis Showalter - Ann Arbor MI, US
Scott Larsen - South Lyon MI, US
Peter Lucas - Ann Arbor MI, US
Hiroyuki Koga - Tokyo, JP
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 31/41
US Classification:
514381, 514382, 514383, 514384
Abstract:
The present invention provides compositions and methods for treating inflammatory conditions (e. g. , of the bowel). In particular, the present invention provides methods of treating (e. g. , therapeutically and/or prophylactically treating) inflammatory conditions (e. g. , of the bowel), compositions useful for such methods (e. g. , antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e. g. therapeutic and preventative medicine) and research applications.