Inventors:
Jess G. Thoene - Ann Arbor MI, US
Assignee:
The Administrators of The Tulane Educational Fund - New Orleans LA
International Classification:
C12P 13/12, A61K 38/05, A61P 35/00, G01N 33/574, C12N 5/09
US Classification:
435113, 514 2191, 435 723, 435344
Abstract:
Pharmaceutical compositions and kits useful for the treatment of cancer include certain alkyl esters of cystine and certain alkyl-substituted cystamine derived esters, including, for example, cystine dimethyl ester and a di-alkyl peptidyl cystamine ester, among others. These compounds may be employed in methods of treating cancers or methods of determining sensitivity of certain cancer cells to apoptosis alone, or in combination with other chemotherapeutic, radiological or apoptotic agents.