PROF. PAUL WESLEY BRANDT-RAUF, M.D.
Osteopathic Medicine at Michael Dr, Scarsdale, NY
License number
New York 143020
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
40 Michael Dr, Scarsdale, NY 10583
Phone
(646) 417-4250
Personal information
See more information about PAUL WESLEY BRANDT-RAUF at radaris.comName
Address
Phone
New Rochelle, NY
40 Michael Dr, Scarsdale, NY 10583
Professional information
Dr. Paul W Brandt-Rauf, Scarsdale NY - MD (Doctor of Medicine)
Specialties:
Internal Medicine, Occupational Medicine, Preventive Occupational Medicine
Address:
40 Michael Dr, Scarsdale 10583
(646) 417-4250 (Phone)
(646) 417-4250 (Phone)
Certifications:
Internal Medicine, 1984, Occupational Medicine, 1986
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Columbia University / College of Physicians And Surgeons
Graduated: 1979
New York-Presbyterian Hospital
Georgetown University Hospital
Columbia University / College of Physicians And Surgeons
Graduated: 1979
New York-Presbyterian Hospital
Georgetown University Hospital
C-Terminal P53 Palindromic Peptide That Induces Apoptosis Of Cells With Aberrant P53 And Uses Thereof
US Patent:
2007017, Jul 26, 2007
Filed:
Jan 27, 2005
Appl. No.:
10/587606
Inventors:
Robert Fine - Tenafly NJ, US
Paul Brandt-Rauf - Scarsdale NY, US
Yueha Mao - New York NY, US
Paul Brandt-Rauf - Scarsdale NY, US
Yueha Mao - New York NY, US
International Classification:
A61K 38/16, C07K 14/47, C07H 21/04, C12P 21/06, C12N 15/86
US Classification:
514012000, 530324000, 435069100, 435320100, 435325000, 435456000, 536023200
Abstract:
Disclosed are polypeptides comprising a first segment of continuous amino acids having the sequence AQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD (SEQ ID NO. 1) covalently linked to a second segment of continuous amino acids having the sequence DSDPGETKFMLKKHRSTSQGKKSKLHSSHARSGGPEKGAQA (SEQ ID NO. 2), or at least two of each covalently linked to each ether. The polypeptides are shown to induce apoptosis of cancer cells that contain mutant p53 or over-expressed wild-type p53.